Mutations of FLT3 receptor affect its surface glycosylation, intracellular localization, and downstream signaling

This review describes the effects of FLT3 mutations that alter its intracellular localization and modify its glycosylation, leading to differences in downstream signaling pathways. The most common type of FLT3 mutation, internal tandem duplication (FLT3-ITD), leads to localization in the endoplasmic...

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Detalles Bibliográficos
Autor principal: Takahashi, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911968/
https://www.ncbi.nlm.nih.gov/pubmed/31853441
http://dx.doi.org/10.1016/j.lrr.2019.100187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911968/
https://www.ncbi.nlm.nih.gov/pubmed/31853441
http://dx.doi.org/10.1016/j.lrr.2019.100187

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