Ketone bodies, stress response, and redox homeostasis

The ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate, as it regulates a broad range of physiological processes at cellular and systemic levels. Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an antioxidant defense program...

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Detalles Bibliográficos
Autores principales: Rojas-Morales, Pedro, Pedraza-Chaverri, José, Tapia, Edilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Graphical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911969/
https://www.ncbi.nlm.nih.gov/pubmed/31926621
http://dx.doi.org/10.1016/j.redox.2019.101395
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author Rojas-Morales, Pedro
Pedraza-Chaverri, José
Tapia, Edilia
author_facet Rojas-Morales, Pedro
Pedraza-Chaverri, José
Tapia, Edilia
author_sort Rojas-Morales, Pedro
collection PubMed
description The ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate, as it regulates a broad range of physiological processes at cellular and systemic levels. Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an antioxidant defense program to maintain redox homeostasis in response to environmental and metabolic challenges, such as ischemia. This property of β-hydroxybutyrate might be key for the beneficial effect of calorie restriction on stress response and disease processes.
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spelling pubmed-69119692019-12-18 Ketone bodies, stress response, and redox homeostasis Rojas-Morales, Pedro Pedraza-Chaverri, José Tapia, Edilia Redox Biol Graphical Review The ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate, as it regulates a broad range of physiological processes at cellular and systemic levels. Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an antioxidant defense program to maintain redox homeostasis in response to environmental and metabolic challenges, such as ischemia. This property of β-hydroxybutyrate might be key for the beneficial effect of calorie restriction on stress response and disease processes. Elsevier 2019-11-28 /pmc/articles/PMC6911969/ /pubmed/31926621 http://dx.doi.org/10.1016/j.redox.2019.101395 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Graphical Review
Rojas-Morales, Pedro
Pedraza-Chaverri, José
Tapia, Edilia
Ketone bodies, stress response, and redox homeostasis
title Ketone bodies, stress response, and redox homeostasis
title_full Ketone bodies, stress response, and redox homeostasis
title_fullStr Ketone bodies, stress response, and redox homeostasis
title_full_unstemmed Ketone bodies, stress response, and redox homeostasis
title_short Ketone bodies, stress response, and redox homeostasis
title_sort ketone bodies, stress response, and redox homeostasis
topic Graphical Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911969/
https://www.ncbi.nlm.nih.gov/pubmed/31926621
http://dx.doi.org/10.1016/j.redox.2019.101395
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