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Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population
We assessed the clinical utility of contrast‐enhanced ultrasonography (CEUS) in the diagnosis of benign and malignant small renal masses using a meta‐analysis of diagnostic test. We performed a comprehensive online search in the following database including PubMed, Embase, Web of Science, Wanfang, a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912038/ https://www.ncbi.nlm.nih.gov/pubmed/31642189 http://dx.doi.org/10.1002/cam4.2635 |
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author | Shen, Lin Li, Yanyan Li, Na Zhao, Yajie Zhou, Qin Li, Zhanzhan |
author_facet | Shen, Lin Li, Yanyan Li, Na Zhao, Yajie Zhou, Qin Li, Zhanzhan |
author_sort | Shen, Lin |
collection | PubMed |
description | We assessed the clinical utility of contrast‐enhanced ultrasonography (CEUS) in the diagnosis of benign and malignant small renal masses using a meta‐analysis of diagnostic test. We performed a comprehensive online search in the following database including PubMed, Embase, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure from the inception to August 25, 2019. the following index were calculated for assessing the diagnostic ability, including sensitivity, specificity, diagnostic odds ratio (DOR), negative likelihood ratio (NLR), positive likelihood ratio (PLR), area under the curve (AUC) with 95% confidence intervals (CIs). Seventeen studies were included in the qualitative and quantitative analyses. The overall sensitivity was 0.93 with 95% CI of 0.88‐0.95. The specificity was 0.71 and the 95% CI was 0.60‐0.80. The pooled AUC was 0.91 (95% CI: 0.88‐0.93). The diagnostic odds ratio was 31 (95% CI: 21‐45). The NLR and PLR were 0.10 (95% CI: 0.07‐0.15) and 3.2(95% CI: 2.3‐4.4), respectively. There is a slight heterogeneity within studies. The subgroup analysis was also performed. For retrospective and perspective, the sensitivity and specificity were 0.93, 0.92 and 0.71, 0.73; For different diameter lesions, the sensitivity and specificity were 0.93, 0.94 and 0.64, 0.74; For sample size (≤median vs. >median), the sensitivity and specificity were 0.94, 0.93 and 0.67, 0.77. The Deek's funnel plot asymmetry test in indicated no publication bias. The CEUS have a high diagnostic ability in differentiating benign and malignant small renal masses among Asian population. |
format | Online Article Text |
id | pubmed-6912038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69120382019-12-23 Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population Shen, Lin Li, Yanyan Li, Na Zhao, Yajie Zhou, Qin Li, Zhanzhan Cancer Med Clinical Cancer Research We assessed the clinical utility of contrast‐enhanced ultrasonography (CEUS) in the diagnosis of benign and malignant small renal masses using a meta‐analysis of diagnostic test. We performed a comprehensive online search in the following database including PubMed, Embase, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure from the inception to August 25, 2019. the following index were calculated for assessing the diagnostic ability, including sensitivity, specificity, diagnostic odds ratio (DOR), negative likelihood ratio (NLR), positive likelihood ratio (PLR), area under the curve (AUC) with 95% confidence intervals (CIs). Seventeen studies were included in the qualitative and quantitative analyses. The overall sensitivity was 0.93 with 95% CI of 0.88‐0.95. The specificity was 0.71 and the 95% CI was 0.60‐0.80. The pooled AUC was 0.91 (95% CI: 0.88‐0.93). The diagnostic odds ratio was 31 (95% CI: 21‐45). The NLR and PLR were 0.10 (95% CI: 0.07‐0.15) and 3.2(95% CI: 2.3‐4.4), respectively. There is a slight heterogeneity within studies. The subgroup analysis was also performed. For retrospective and perspective, the sensitivity and specificity were 0.93, 0.92 and 0.71, 0.73; For different diameter lesions, the sensitivity and specificity were 0.93, 0.94 and 0.64, 0.74; For sample size (≤median vs. >median), the sensitivity and specificity were 0.94, 0.93 and 0.67, 0.77. The Deek's funnel plot asymmetry test in indicated no publication bias. The CEUS have a high diagnostic ability in differentiating benign and malignant small renal masses among Asian population. John Wiley and Sons Inc. 2019-10-23 /pmc/articles/PMC6912038/ /pubmed/31642189 http://dx.doi.org/10.1002/cam4.2635 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Shen, Lin Li, Yanyan Li, Na Zhao, Yajie Zhou, Qin Li, Zhanzhan Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population |
title | Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population |
title_full | Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population |
title_fullStr | Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population |
title_full_unstemmed | Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population |
title_short | Clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among Asian population |
title_sort | clinical utility of contrast‐enhanced ultrasonography in the diagnosis of benign and malignant small renal masses among asian population |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912038/ https://www.ncbi.nlm.nih.gov/pubmed/31642189 http://dx.doi.org/10.1002/cam4.2635 |
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