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Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer

Pancreatic cancer (PC) is a highly malignant tumor with increased morbidity and mortality, which is difficult to diagnose and cure in the clinic. Through secreting exosomes containing biological molecules, including diverse RNAs and proteins, bone marrow mesenchymal stem cells (BM‐MSCs) influence th...

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Autores principales: Shang, Song, Wang, Jinfeng, Chen, Shilin, Tian, Renyun, Zeng, Hui, Wang, Liang, Xia, Man, Zhu, Haizhen, Zuo, Chaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912060/
https://www.ncbi.nlm.nih.gov/pubmed/31642612
http://dx.doi.org/10.1002/cam4.2633
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author Shang, Song
Wang, Jinfeng
Chen, Shilin
Tian, Renyun
Zeng, Hui
Wang, Liang
Xia, Man
Zhu, Haizhen
Zuo, Chaohui
author_facet Shang, Song
Wang, Jinfeng
Chen, Shilin
Tian, Renyun
Zeng, Hui
Wang, Liang
Xia, Man
Zhu, Haizhen
Zuo, Chaohui
author_sort Shang, Song
collection PubMed
description Pancreatic cancer (PC) is a highly malignant tumor with increased morbidity and mortality, which is difficult to diagnose and cure in the clinic. Through secreting exosomes containing biological molecules, including diverse RNAs and proteins, bone marrow mesenchymal stem cells (BM‐MSCs) influence the immunity, inflammation, tumor environment, and cancer metastasis. In this study, low expression of miRNA‐1231 (miR‐1231) in exosomes derived from the peripheral blood was significantly correlated with the TNM stage of PC, suggesting the potential inhibitory effect of exosomal miR‐1231 on PC occurrence and development. The proliferation, migration, invasion, and adhesion to the matrix of PC cells BxPC‐3 and PANC‐1 were negatively regulated by exosomes derived from the supernatants of BM‐MSCs that transfected with miR‐1231 oligonucleotides. Simultaneously, tumor growth in vivo was seriously restrained in BALB/C nude mice by tail vein injection with exosomes originated from BM‐MSCs that transfected with miR‐1231 mimics. The exosomes extracted from BM‐MSCs with high level of miR‐1231 inhibit the activity of PC, providing the potential application for developing new and efficient medicine for cancer therapy, especially for PC treatment. The exosomal miR‐1231 of peripheral blood may also be a potential indicator for PC diagnosis in the future.
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spelling pubmed-69120602019-12-23 Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer Shang, Song Wang, Jinfeng Chen, Shilin Tian, Renyun Zeng, Hui Wang, Liang Xia, Man Zhu, Haizhen Zuo, Chaohui Cancer Med Cancer Biology Pancreatic cancer (PC) is a highly malignant tumor with increased morbidity and mortality, which is difficult to diagnose and cure in the clinic. Through secreting exosomes containing biological molecules, including diverse RNAs and proteins, bone marrow mesenchymal stem cells (BM‐MSCs) influence the immunity, inflammation, tumor environment, and cancer metastasis. In this study, low expression of miRNA‐1231 (miR‐1231) in exosomes derived from the peripheral blood was significantly correlated with the TNM stage of PC, suggesting the potential inhibitory effect of exosomal miR‐1231 on PC occurrence and development. The proliferation, migration, invasion, and adhesion to the matrix of PC cells BxPC‐3 and PANC‐1 were negatively regulated by exosomes derived from the supernatants of BM‐MSCs that transfected with miR‐1231 oligonucleotides. Simultaneously, tumor growth in vivo was seriously restrained in BALB/C nude mice by tail vein injection with exosomes originated from BM‐MSCs that transfected with miR‐1231 mimics. The exosomes extracted from BM‐MSCs with high level of miR‐1231 inhibit the activity of PC, providing the potential application for developing new and efficient medicine for cancer therapy, especially for PC treatment. The exosomal miR‐1231 of peripheral blood may also be a potential indicator for PC diagnosis in the future. John Wiley and Sons Inc. 2019-10-23 /pmc/articles/PMC6912060/ /pubmed/31642612 http://dx.doi.org/10.1002/cam4.2633 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Shang, Song
Wang, Jinfeng
Chen, Shilin
Tian, Renyun
Zeng, Hui
Wang, Liang
Xia, Man
Zhu, Haizhen
Zuo, Chaohui
Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
title Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
title_full Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
title_fullStr Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
title_full_unstemmed Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
title_short Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
title_sort exosomal mirna‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912060/
https://www.ncbi.nlm.nih.gov/pubmed/31642612
http://dx.doi.org/10.1002/cam4.2633
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