Pharmacological Modulation of the Wnt/β-Catenin Pathway Inhibits Proliferation and Promotes Differentiation of Long-Lived Memory CD4(+) T Cells in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques

The major obstacle to human immunodeficiency type 1 virus (HIV-1) eradication is a reservoir of latently infected cells that persists despite long-term antiretroviral therapy (ART) and is maintained through cellular proliferation. Long-lived memory CD4(+) T cells with high self-renewal capacity, suc...

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Detalles Bibliográficos
Autores principales: Mavigner, M., Zanoni, M., Tharp, G. K., Habib, J., Mattingly, C. R., Lichterfeld, M., Nega, M. T., Vanderford, T. H., Bosinger, S. E., Chahroudi, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912121/
https://www.ncbi.nlm.nih.gov/pubmed/31619550
http://dx.doi.org/10.1128/JVI.01094-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912121/
https://www.ncbi.nlm.nih.gov/pubmed/31619550
http://dx.doi.org/10.1128/JVI.01094-19

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