Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presenta...

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Detalles Bibliográficos
Autores principales: Jallow, Sabelle, Wilmshurst, Jo M, Howard, Wayne, Copelyn, Julie, Seakamela, Lerato, Chan, Koon-Wing, Sebunya, Robert, Sibiya, Rosinah, Du Plessis, Heleen, Jacobs, Charlene, Berkowitz, Natacha, Blumberg, Lucille, McCarthy, Kerrigan, Maseti, Elizabeth, Kamupira, Mercy, Dlamini, Nonhlanhla, Gumede, Nicksy, Diop, Ousmane M, Lau, Yu Lung, Moonsamy, Shelina, Eley, Brian, Suchard, Melinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports and Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912151/
https://www.ncbi.nlm.nih.gov/pubmed/31086993
http://dx.doi.org/10.1093/cid/ciz361
Descripción
Sumario:Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child’s perinatal exposure to human immunodeficiency virus.

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