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Cysteamine inhibits lysosomal oxidation of low density lipoprotein in human macrophages and reduces atherosclerosis in mice

BACKGROUND AND AIMS: We have shown previously that low density lipoprotein (LDL) aggregated by vortexing is internalised by macrophages and oxidised by iron in lysosomes to form the advanced lipid/protein oxidation product ceroid. We have now used sphingomyelinase-aggregated LDL, a more pathophysiol...

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Detalles Bibliográficos
Autores principales:	Wen, Yichuan, Ahmad, Feroz, Mohri, Zahra, Weinberg, Peter D., Leake, David S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912160/ https://www.ncbi.nlm.nih.gov/pubmed/31629988 http://dx.doi.org/10.1016/j.atherosclerosis.2019.09.019

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