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10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest
Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912173/ https://www.ncbi.nlm.nih.gov/pubmed/31857975 http://dx.doi.org/10.15171/apb.2019.080 |
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author | Rasmussen, Andrea Murphy, Kaylee Hoskin, David W. |
author_facet | Rasmussen, Andrea Murphy, Kaylee Hoskin, David W. |
author_sort | Rasmussen, Andrea |
collection | PubMed |
description | Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cell proliferation, cytotoxicity and cell cycle progression, and western blotting was used to measure cyclin protein expression. Results: Ovarian cancer cells that were treated with 10-gingerol experienced a time- and dose-dependent decrease in cell number, which was due to a reduction in cell proliferation rather than a cytotoxic effect. Reduced proliferation of 10-gingerol-treated ovarian cancer cells was associated with an increased percentage of cells in G2 phase of the cell cycle and a corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-gingerol. Conclusion: These findings revealed that 10-gingerol caused a G2 arrest-associated suppression of ovarian cancer cell growth, which may be exploited in the management of ovarian cancer. |
format | Online Article Text |
id | pubmed-6912173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-69121732019-12-19 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest Rasmussen, Andrea Murphy, Kaylee Hoskin, David W. Adv Pharm Bull Short Communication Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cell proliferation, cytotoxicity and cell cycle progression, and western blotting was used to measure cyclin protein expression. Results: Ovarian cancer cells that were treated with 10-gingerol experienced a time- and dose-dependent decrease in cell number, which was due to a reduction in cell proliferation rather than a cytotoxic effect. Reduced proliferation of 10-gingerol-treated ovarian cancer cells was associated with an increased percentage of cells in G2 phase of the cell cycle and a corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-gingerol. Conclusion: These findings revealed that 10-gingerol caused a G2 arrest-associated suppression of ovarian cancer cell growth, which may be exploited in the management of ovarian cancer. Tabriz University of Medical Sciences 2019-10 2019-10-24 /pmc/articles/PMC6912173/ /pubmed/31857975 http://dx.doi.org/10.15171/apb.2019.080 Text en © 2019 The Author (s) http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers. |
spellingShingle | Short Communication Rasmussen, Andrea Murphy, Kaylee Hoskin, David W. 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
title | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
title_full | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
title_fullStr | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
title_full_unstemmed | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
title_short | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
title_sort | 10-gingerol inhibits ovarian cancer cell growth by inducing g2 arrest |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912173/ https://www.ncbi.nlm.nih.gov/pubmed/31857975 http://dx.doi.org/10.15171/apb.2019.080 |
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