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Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents

Innovations in pharmaceutical research are striving for designing newer drug therapies to eradicate deadly diseases. Strategies for such inventions always flourish with keys and objectives of minimal adverse effects and effective treatment. Recent trends in pharmaceutical technology specify that muc...

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Autores principales: Komati, Someshwar, Swain, Suryakanta, Rao, Muddana Eswara Bhanoji, Jena, Bikash Ranjan, Dasi, Vishali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912179/
https://www.ncbi.nlm.nih.gov/pubmed/31857957
http://dx.doi.org/10.15171/apb.2019.062
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author Komati, Someshwar
Swain, Suryakanta
Rao, Muddana Eswara Bhanoji
Jena, Bikash Ranjan
Dasi, Vishali
author_facet Komati, Someshwar
Swain, Suryakanta
Rao, Muddana Eswara Bhanoji
Jena, Bikash Ranjan
Dasi, Vishali
author_sort Komati, Someshwar
collection PubMed
description Innovations in pharmaceutical research are striving for designing newer drug therapies to eradicate deadly diseases. Strategies for such inventions always flourish with keys and objectives of minimal adverse effects and effective treatment. Recent trends in pharmaceutical technology specify that mucoadhesive drug delivery system is particularly appropriate than oral control release, for getting local systematic delivery of drugs in GIT for an extended interval of time at a predetermined rate. However, it is somehow expensive and unpleasant sensation for some patients, but still it is needful for getting short enzymatic activity, simple administration without pain and evasion of fast pass metabolism. Usually the vehicles employed in drug delivery of mucoadhesive system have a significant impact that draws further attention to potential benefits like improved bioavailability of therapeutic agents, extensive drug residence time at the site of administration and a comparatively faster drug uptake into the systemic circulation. The drug release from mucoadhesive multiparticulates is contingent on several types of factors comprising carrier need to produce the multiparticles and quantity of medication drug contained in them. Mucoadhesion is characterized by selected theories and mechanisms. Various strategies emergent in mucoadhesive multiparticulate drug delivery system (MMDDS) by in-vitro as well as ex-vivo description and characterization are also critically discussed. Apart from these, the primary focus during this review is to highlight current patents, clinical status, and regulatory policy for enhancement of mucoadhesive multi-particulate drug delivery system in the present scenario.
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spelling pubmed-69121792019-12-19 Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents Komati, Someshwar Swain, Suryakanta Rao, Muddana Eswara Bhanoji Jena, Bikash Ranjan Dasi, Vishali Adv Pharm Bull Review Article Innovations in pharmaceutical research are striving for designing newer drug therapies to eradicate deadly diseases. Strategies for such inventions always flourish with keys and objectives of minimal adverse effects and effective treatment. Recent trends in pharmaceutical technology specify that mucoadhesive drug delivery system is particularly appropriate than oral control release, for getting local systematic delivery of drugs in GIT for an extended interval of time at a predetermined rate. However, it is somehow expensive and unpleasant sensation for some patients, but still it is needful for getting short enzymatic activity, simple administration without pain and evasion of fast pass metabolism. Usually the vehicles employed in drug delivery of mucoadhesive system have a significant impact that draws further attention to potential benefits like improved bioavailability of therapeutic agents, extensive drug residence time at the site of administration and a comparatively faster drug uptake into the systemic circulation. The drug release from mucoadhesive multiparticulates is contingent on several types of factors comprising carrier need to produce the multiparticles and quantity of medication drug contained in them. Mucoadhesion is characterized by selected theories and mechanisms. Various strategies emergent in mucoadhesive multiparticulate drug delivery system (MMDDS) by in-vitro as well as ex-vivo description and characterization are also critically discussed. Apart from these, the primary focus during this review is to highlight current patents, clinical status, and regulatory policy for enhancement of mucoadhesive multi-particulate drug delivery system in the present scenario. Tabriz University of Medical Sciences 2019-10 2019-10-24 /pmc/articles/PMC6912179/ /pubmed/31857957 http://dx.doi.org/10.15171/apb.2019.062 Text en © 2019 The Author (s) http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
spellingShingle Review Article
Komati, Someshwar
Swain, Suryakanta
Rao, Muddana Eswara Bhanoji
Jena, Bikash Ranjan
Dasi, Vishali
Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents
title Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents
title_full Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents
title_fullStr Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents
title_full_unstemmed Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents
title_short Mucoadhesive Multiparticulate Drug Delivery Systems: An Extensive Review of Patents
title_sort mucoadhesive multiparticulate drug delivery systems: an extensive review of patents
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912179/
https://www.ncbi.nlm.nih.gov/pubmed/31857957
http://dx.doi.org/10.15171/apb.2019.062
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