A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells

Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar disorder, inhibits GSK3 via Mg(+) competition and increased Ser21 (GSK3α) or Ser9 (GSK3β) phosphorylation, leading t...

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Detalles Bibliográficos
Autores principales: Kurgan, Nigel, Whitley, Kennedy C., Maddalena, Lucas A., Moradi, Fereshteh, Stoikos, Joshua, Hamstra, Sophie I., Rubie, Elizabeth A., Kumar, Megha, Roy, Brian D., Woodgett, James R., Stuart, Jeffrey A., Fajardo, Val A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912290/
https://www.ncbi.nlm.nih.gov/pubmed/31671858
http://dx.doi.org/10.3390/cells8111340

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