Cargando…

Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component

Leukocytes and cytokines in blood units have been known to be involved in febrile non-hemolytic transfusion reaction (FNHTR), and these adverse reactions still occur while using pre-storage leukoreduced blood products. Blood transfusion is similar to transplantation because both implant allogeneic c...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Ying-Hao, Lin, Wei-Tzu, Wang, Wei-Ting, Chiueh, Tzong-Shi, Chen, Ding-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912294/
https://www.ncbi.nlm.nih.gov/pubmed/31766247
http://dx.doi.org/10.3390/jcm8111961
_version_ 1783479422057185280
author Wen, Ying-Hao
Lin, Wei-Tzu
Wang, Wei-Ting
Chiueh, Tzong-Shi
Chen, Ding-Ping
author_facet Wen, Ying-Hao
Lin, Wei-Tzu
Wang, Wei-Ting
Chiueh, Tzong-Shi
Chen, Ding-Ping
author_sort Wen, Ying-Hao
collection PubMed
description Leukocytes and cytokines in blood units have been known to be involved in febrile non-hemolytic transfusion reaction (FNHTR), and these adverse reactions still occur while using pre-storage leukoreduced blood products. Blood transfusion is similar to transplantation because both implant allogeneic cells or organs into the recipient. CTLA4 gene polymorphism was found to be associated with graft-versus-host disease in hematopoietic stem cell transplantation. We performed a prospective cohort study at a major tertiary care center to investigate the correlation of CTLA4 gene polymorphism and transfusion reactions. Selected CTLA4 gene SNPs were genotyped and compared between patients with transfusion-associated adverse reactions (TAARs) and healthy controls. Nineteen patients and 20 healthy subjects were enrolled. There were 4 SNPs showing differences in allele frequency between patients and controls, and the frequency of “A” allele of rs4553808, “G” allele of rs62182595, “G” allele of rs16840252, and “C” allele of rs5742909 were significantly higher in patients than in controls. Moreover, these alleles also showed significantly higher risk of TAARs (OR = 2.357, 95%CI: 1.584–3.508, p = 0.02; OR = 2.357, 95%CI: 1.584–3.508, p = 0.02; OR = 2.462, 95%CI: 1.619–3.742, p = 0.008; OR = 2.357, 95%CI: 1.584–3.508, p = 0.02; OR = 2.357, 95%CI: 1.584–3.508, p = 0.02, respectively). The present study demonstrated the correlation of CTLA4 gene polymorphism and transfusion reaction, and alleles of 4 CTLA4 SNPs with an increased risk of TAARs were found. It is important to explore the potential immune regulatory mechanism affected by SNPs of costimulatory molecules, and it could predict transfusion reaction occurrence and guide preventive actions.
format Online
Article
Text
id pubmed-6912294
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69122942020-01-02 Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component Wen, Ying-Hao Lin, Wei-Tzu Wang, Wei-Ting Chiueh, Tzong-Shi Chen, Ding-Ping J Clin Med Article Leukocytes and cytokines in blood units have been known to be involved in febrile non-hemolytic transfusion reaction (FNHTR), and these adverse reactions still occur while using pre-storage leukoreduced blood products. Blood transfusion is similar to transplantation because both implant allogeneic cells or organs into the recipient. CTLA4 gene polymorphism was found to be associated with graft-versus-host disease in hematopoietic stem cell transplantation. We performed a prospective cohort study at a major tertiary care center to investigate the correlation of CTLA4 gene polymorphism and transfusion reactions. Selected CTLA4 gene SNPs were genotyped and compared between patients with transfusion-associated adverse reactions (TAARs) and healthy controls. Nineteen patients and 20 healthy subjects were enrolled. There were 4 SNPs showing differences in allele frequency between patients and controls, and the frequency of “A” allele of rs4553808, “G” allele of rs62182595, “G” allele of rs16840252, and “C” allele of rs5742909 were significantly higher in patients than in controls. Moreover, these alleles also showed significantly higher risk of TAARs (OR = 2.357, 95%CI: 1.584–3.508, p = 0.02; OR = 2.357, 95%CI: 1.584–3.508, p = 0.02; OR = 2.462, 95%CI: 1.619–3.742, p = 0.008; OR = 2.357, 95%CI: 1.584–3.508, p = 0.02; OR = 2.357, 95%CI: 1.584–3.508, p = 0.02, respectively). The present study demonstrated the correlation of CTLA4 gene polymorphism and transfusion reaction, and alleles of 4 CTLA4 SNPs with an increased risk of TAARs were found. It is important to explore the potential immune regulatory mechanism affected by SNPs of costimulatory molecules, and it could predict transfusion reaction occurrence and guide preventive actions. MDPI 2019-11-13 /pmc/articles/PMC6912294/ /pubmed/31766247 http://dx.doi.org/10.3390/jcm8111961 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wen, Ying-Hao
Lin, Wei-Tzu
Wang, Wei-Ting
Chiueh, Tzong-Shi
Chen, Ding-Ping
Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component
title Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component
title_full Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component
title_fullStr Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component
title_full_unstemmed Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component
title_short Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component
title_sort association of ctla4 gene polymorphism with transfusion reaction after infusion of leukoreduced blood component
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912294/
https://www.ncbi.nlm.nih.gov/pubmed/31766247
http://dx.doi.org/10.3390/jcm8111961
work_keys_str_mv AT wenyinghao associationofctla4genepolymorphismwithtransfusionreactionafterinfusionofleukoreducedbloodcomponent
AT linweitzu associationofctla4genepolymorphismwithtransfusionreactionafterinfusionofleukoreducedbloodcomponent
AT wangweiting associationofctla4genepolymorphismwithtransfusionreactionafterinfusionofleukoreducedbloodcomponent
AT chiuehtzongshi associationofctla4genepolymorphismwithtransfusionreactionafterinfusionofleukoreducedbloodcomponent
AT chendingping associationofctla4genepolymorphismwithtransfusionreactionafterinfusionofleukoreducedbloodcomponent