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The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing

Background: Wound healing of the nasal mucosa after endoscopic sinus surgery (ESS) is frequently complicated by scaring and consequently recurrences are encountered. Methods of optimizing results have been sought. In the present study we evaluated the effects of a powerful antioxidant, astaxanthin,...

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Autores principales: Manciula, Lavinia-Gianina, Berce, Cristian, Tabaran, Flaviu, Trombitaș, Veronica, Albu, Silviu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912356/
https://www.ncbi.nlm.nih.gov/pubmed/31718054
http://dx.doi.org/10.3390/jcm8111941
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author Manciula, Lavinia-Gianina
Berce, Cristian
Tabaran, Flaviu
Trombitaș, Veronica
Albu, Silviu
author_facet Manciula, Lavinia-Gianina
Berce, Cristian
Tabaran, Flaviu
Trombitaș, Veronica
Albu, Silviu
author_sort Manciula, Lavinia-Gianina
collection PubMed
description Background: Wound healing of the nasal mucosa after endoscopic sinus surgery (ESS) is frequently complicated by scaring and consequently recurrences are encountered. Methods of optimizing results have been sought. In the present study we evaluated the effects of a powerful antioxidant, astaxanthin, on nasal mucosa healing after surgery, comparing it to the extensively studied properties of dexamethasone. Materials and Methods: 63 Wistar rats were used. The nasal mucosa from one side was damaged employing the brushing method. They were randomly divided into three experimental groups, one treated with astaxanthin, the second treated with dexamethasone and the third one acted as the control and was given normal saline. The rats were killed on days 5, 14 and 28 following injury. We observed the temporal evolution of the wound healing process and quantified the results by assessing four parameters: the epithelial thickness index (ETI), the subepithelial thickness index (STI), the goblet cell count and the subepithelial fibrosis index (SFI). Results: At 28 days, the ETI was significantly lower in the astaxanthin group (p < 0.05) compared to the other two groups. The STI was also lower in the astaxanthin group (p < 0.05), but comparable to the dexamethasone group at 28 days. The goblet cell count was higher in the astaxanthin group. The SFI had similar results in both dexamethasone and astaxanthin groups, with lower values compared to the control group. In the astaxanthin group there was no synechia formation. Conclusion: Astaxanthin given in the post injury period significantly decreases fibrosis, inhibits synechia development and significantly decreases subepithelial fibrosis. Moreover, it has no general or local toxic effects.
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spelling pubmed-69123562020-01-02 The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing Manciula, Lavinia-Gianina Berce, Cristian Tabaran, Flaviu Trombitaș, Veronica Albu, Silviu J Clin Med Article Background: Wound healing of the nasal mucosa after endoscopic sinus surgery (ESS) is frequently complicated by scaring and consequently recurrences are encountered. Methods of optimizing results have been sought. In the present study we evaluated the effects of a powerful antioxidant, astaxanthin, on nasal mucosa healing after surgery, comparing it to the extensively studied properties of dexamethasone. Materials and Methods: 63 Wistar rats were used. The nasal mucosa from one side was damaged employing the brushing method. They were randomly divided into three experimental groups, one treated with astaxanthin, the second treated with dexamethasone and the third one acted as the control and was given normal saline. The rats were killed on days 5, 14 and 28 following injury. We observed the temporal evolution of the wound healing process and quantified the results by assessing four parameters: the epithelial thickness index (ETI), the subepithelial thickness index (STI), the goblet cell count and the subepithelial fibrosis index (SFI). Results: At 28 days, the ETI was significantly lower in the astaxanthin group (p < 0.05) compared to the other two groups. The STI was also lower in the astaxanthin group (p < 0.05), but comparable to the dexamethasone group at 28 days. The goblet cell count was higher in the astaxanthin group. The SFI had similar results in both dexamethasone and astaxanthin groups, with lower values compared to the control group. In the astaxanthin group there was no synechia formation. Conclusion: Astaxanthin given in the post injury period significantly decreases fibrosis, inhibits synechia development and significantly decreases subepithelial fibrosis. Moreover, it has no general or local toxic effects. MDPI 2019-11-11 /pmc/articles/PMC6912356/ /pubmed/31718054 http://dx.doi.org/10.3390/jcm8111941 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manciula, Lavinia-Gianina
Berce, Cristian
Tabaran, Flaviu
Trombitaș, Veronica
Albu, Silviu
The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing
title The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing
title_full The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing
title_fullStr The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing
title_full_unstemmed The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing
title_short The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing
title_sort effects of postoperative astaxanthin administration on nasal mucosa wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912356/
https://www.ncbi.nlm.nih.gov/pubmed/31718054
http://dx.doi.org/10.3390/jcm8111941
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