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Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation

Islet transplantation has been demonstrated to provide superior glycemic control with reduced glucose lability and hypoglycemic events compared with standard insulin therapy. However, the insulin independence rate after islet transplantation from one donor pancreas has remained low. The low frequenc...

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Detalles Bibliográficos
Autor principal: Noguchi, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912371/
https://www.ncbi.nlm.nih.gov/pubmed/31652814
http://dx.doi.org/10.3390/jcm8111763
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author Noguchi, Hirofumi
author_facet Noguchi, Hirofumi
author_sort Noguchi, Hirofumi
collection PubMed
description Islet transplantation has been demonstrated to provide superior glycemic control with reduced glucose lability and hypoglycemic events compared with standard insulin therapy. However, the insulin independence rate after islet transplantation from one donor pancreas has remained low. The low frequency of islet grafting is dependent on poor islet recovery from donors and early islet loss during the first hours following grafting. The reduction in islet mass during pancreas preservation, islet isolation, and islet transplantation leads to β-cell death by apoptosis and the prerecruitment of intracellular death signaling pathways, such as c-Jun NH(2)-terminal kinase (JNK), which is one of the stress groups of mitogen-activated protein kinases (MAPKs). In this review, we show some of the most recent contributions to the advancement of knowledge of the JNK pathway and several possibilities for the treatment of diabetes using JNK inhibitors.
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spelling pubmed-69123712020-01-02 Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation Noguchi, Hirofumi J Clin Med Review Islet transplantation has been demonstrated to provide superior glycemic control with reduced glucose lability and hypoglycemic events compared with standard insulin therapy. However, the insulin independence rate after islet transplantation from one donor pancreas has remained low. The low frequency of islet grafting is dependent on poor islet recovery from donors and early islet loss during the first hours following grafting. The reduction in islet mass during pancreas preservation, islet isolation, and islet transplantation leads to β-cell death by apoptosis and the prerecruitment of intracellular death signaling pathways, such as c-Jun NH(2)-terminal kinase (JNK), which is one of the stress groups of mitogen-activated protein kinases (MAPKs). In this review, we show some of the most recent contributions to the advancement of knowledge of the JNK pathway and several possibilities for the treatment of diabetes using JNK inhibitors. MDPI 2019-10-23 /pmc/articles/PMC6912371/ /pubmed/31652814 http://dx.doi.org/10.3390/jcm8111763 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Noguchi, Hirofumi
Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
title Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
title_full Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
title_fullStr Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
title_full_unstemmed Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
title_short Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
title_sort regulation of c-jun nh(2)-terminal kinase for islet transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912371/
https://www.ncbi.nlm.nih.gov/pubmed/31652814
http://dx.doi.org/10.3390/jcm8111763
work_keys_str_mv AT noguchihirofumi regulationofcjunnh2terminalkinaseforislettransplantation