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Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis

Cuprizone (CPZ) preferentially affects oligodendrocytes (OLG), resulting in demyelination. To investigate whether central oligodendrocytosis and gliosis triggered an adaptive immune response, the impact of combining a standard (0.2%) or low (0.1%) dose of ingested CPZ with disruption of the blood br...

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Detalles Bibliográficos
Autores principales:	Sen, Monokesh K., Almuslehi, Mohammed S. M., Gyengesi, Erika, Myers, Simon J., Shortland, Peter J., Mahns, David A., Coorssen, Jens R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912385/ https://www.ncbi.nlm.nih.gov/pubmed/31653054 http://dx.doi.org/10.3390/cells8111314

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