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Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice

The presence of the homozygous ‘Pi*Z’ variant of alpha-1 antitrypsin (AAT) (‘Pi*ZZ’ genotype) predisposes to liver fibrosis development, but the role of iron metabolism in this process remains unknown. Therefore, we assessed iron metabolism and variants in the Homeostatic Iron Regulator gene (HFE) a...

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Detalles Bibliográficos
Autores principales:	Guldiken, Nurdan, Hamesch, Karim, Schuller, Shari Malan, Aly, Mahmoud, Lindhauer, Cecilia, Schneider, Carolin V., Fromme, Malin, Trautwein, Christian, Strnad, Pavel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912453/ https://www.ncbi.nlm.nih.gov/pubmed/31717526 http://dx.doi.org/10.3390/cells8111415

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