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Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS)....

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Autores principales: Cavagna, Lorenzo, Trallero-Araguás, Ernesto, Meloni, Federica, Cavazzana, Ilaria, Rojas-Serrano, Jorge, Feist, Eugen, Zanframundo, Giovanni, Morandi, Valentina, Meyer, Alain, Pereira da Silva, Jose Antonio, Matos Costa, Carlo Jorge, Molberg, Oyvind, Andersson, Helena, Codullo, Veronica, Mosca, Marta, Barsotti, Simone, Neri, Rossella, Scirè, Carlo, Govoni, Marcello, Furini, Federica, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Schneider, Udo, Lorenz, Hanns-Martin, Doria, Andrea, Ghirardello, Anna, Ortego-Centeno, Norberto, Confalonieri, Marco, Tomietto, Paola, Pipitone, Nicolò, Rodriguez Cambron, Ana Belen, Blázquez Cañamero, María Ángeles, Voll, Reinhard Edmund, Wendel, Sarah, Scarpato, Salvatore, Maurier, Francois, Limonta, Massimiliano, Colombelli, Paolo, Giannini, Margherita, Geny, Bernard, Arrigoni, Eugenio, Bravi, Elena, Migliorini, Paola, Mathieu, Alessandro, Piga, Matteo, Drott, Ulrich, Delbrueck, Christiane, Bauhammer, Jutta, Cagnotto, Giovanni, Vancheri, Carlo, Sambataro, Gianluca, De Langhe, Ellen, Sainaghi, Pier Paolo, Monti, Cristina, Gigli Berzolari, Francesca, Romano, Mariaeva, Bonella, Francesco, Specker, Christof, Schwarting, Andreas, Villa Blanco, Ignacio, Selmi, Carlo, Ceribelli, Angela, Nuno, Laura, Mera-Varela, Antonio, Perez Gomez, Nair, Fusaro, Enrico, Parisi, Simone, Sinigaglia, Luigi, Del Papa, Nicoletta, Benucci, Maurizio, Cimmino, Marco Amedeo, Riccieri, Valeria, Conti, Fabrizio, Sebastiani, Gian Domenico, Iuliano, Annamaria, Emmi, Giacomo, Cammelli, Daniele, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Paolazzi, Giuseppe, Saketkoo, Lesley Ann, Giorgi, Roberto, Salaffi, Fausto, Cifrian, Jose, Caporali, Roberto, Locatelli, Francesco, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Pozzi, Maria Rosa, Claudia, Lomater, Distler, Jorg, Knitza, Johannes, Schett, George, Iannone, Florenzo, Fornaro, Marco, Franceschini, Franco, Quartuccio, Luca, Gerli, Roberto, Bartoloni, Elena, Bellando Randone, Silvia, Zampogna, Giuseppe, Gonzalez Perez, Montserrat I., Mejia, Mayra, Vicente, Esther, Triantafyllias, Konstantinos, Lopez-Mejias, Raquel, Matucci-Cerinic, Marco, Selva-O’Callaghan, Albert, Castañeda, Santos, Montecucco, Carlomaurizio, Gonzalez-Gay, Miguel Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912490/
https://www.ncbi.nlm.nih.gov/pubmed/31752231
http://dx.doi.org/10.3390/jcm8112013
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author Cavagna, Lorenzo
Trallero-Araguás, Ernesto
Meloni, Federica
Cavazzana, Ilaria
Rojas-Serrano, Jorge
Feist, Eugen
Zanframundo, Giovanni
Morandi, Valentina
Meyer, Alain
Pereira da Silva, Jose Antonio
Matos Costa, Carlo Jorge
Molberg, Oyvind
Andersson, Helena
Codullo, Veronica
Mosca, Marta
Barsotti, Simone
Neri, Rossella
Scirè, Carlo
Govoni, Marcello
Furini, Federica
Lopez-Longo, Francisco Javier
Martinez-Barrio, Julia
Schneider, Udo
Lorenz, Hanns-Martin
Doria, Andrea
Ghirardello, Anna
Ortego-Centeno, Norberto
Confalonieri, Marco
Tomietto, Paola
Pipitone, Nicolò
Rodriguez Cambron, Ana Belen
Blázquez Cañamero, María Ángeles
Voll, Reinhard Edmund
Wendel, Sarah
Scarpato, Salvatore
Maurier, Francois
Limonta, Massimiliano
Colombelli, Paolo
Giannini, Margherita
Geny, Bernard
Arrigoni, Eugenio
Bravi, Elena
Migliorini, Paola
Mathieu, Alessandro
Piga, Matteo
Drott, Ulrich
Delbrueck, Christiane
Bauhammer, Jutta
Cagnotto, Giovanni
Vancheri, Carlo
Sambataro, Gianluca
De Langhe, Ellen
Sainaghi, Pier Paolo
Monti, Cristina
Gigli Berzolari, Francesca
Romano, Mariaeva
Bonella, Francesco
Specker, Christof
Schwarting, Andreas
Villa Blanco, Ignacio
Selmi, Carlo
Ceribelli, Angela
Nuno, Laura
Mera-Varela, Antonio
Perez Gomez, Nair
Fusaro, Enrico
Parisi, Simone
Sinigaglia, Luigi
Del Papa, Nicoletta
Benucci, Maurizio
Cimmino, Marco Amedeo
Riccieri, Valeria
Conti, Fabrizio
Sebastiani, Gian Domenico
Iuliano, Annamaria
Emmi, Giacomo
Cammelli, Daniele
Sebastiani, Marco
Manfredi, Andreina
Bachiller-Corral, Javier
Sifuentes Giraldo, Walter Alberto
Paolazzi, Giuseppe
Saketkoo, Lesley Ann
Giorgi, Roberto
Salaffi, Fausto
Cifrian, Jose
Caporali, Roberto
Locatelli, Francesco
Marchioni, Enrico
Pesci, Alberto
Dei, Giulia
Pozzi, Maria Rosa
Claudia, Lomater
Distler, Jorg
Knitza, Johannes
Schett, George
Iannone, Florenzo
Fornaro, Marco
Franceschini, Franco
Quartuccio, Luca
Gerli, Roberto
Bartoloni, Elena
Bellando Randone, Silvia
Zampogna, Giuseppe
Gonzalez Perez, Montserrat I.
Mejia, Mayra
Vicente, Esther
Triantafyllias, Konstantinos
Lopez-Mejias, Raquel
Matucci-Cerinic, Marco
Selva-O’Callaghan, Albert
Castañeda, Santos
Montecucco, Carlomaurizio
Gonzalez-Gay, Miguel Angel
author_facet Cavagna, Lorenzo
Trallero-Araguás, Ernesto
Meloni, Federica
Cavazzana, Ilaria
Rojas-Serrano, Jorge
Feist, Eugen
Zanframundo, Giovanni
Morandi, Valentina
Meyer, Alain
Pereira da Silva, Jose Antonio
Matos Costa, Carlo Jorge
Molberg, Oyvind
Andersson, Helena
Codullo, Veronica
Mosca, Marta
Barsotti, Simone
Neri, Rossella
Scirè, Carlo
Govoni, Marcello
Furini, Federica
Lopez-Longo, Francisco Javier
Martinez-Barrio, Julia
Schneider, Udo
Lorenz, Hanns-Martin
Doria, Andrea
Ghirardello, Anna
Ortego-Centeno, Norberto
Confalonieri, Marco
Tomietto, Paola
Pipitone, Nicolò
Rodriguez Cambron, Ana Belen
Blázquez Cañamero, María Ángeles
Voll, Reinhard Edmund
Wendel, Sarah
Scarpato, Salvatore
Maurier, Francois
Limonta, Massimiliano
Colombelli, Paolo
Giannini, Margherita
Geny, Bernard
Arrigoni, Eugenio
Bravi, Elena
Migliorini, Paola
Mathieu, Alessandro
Piga, Matteo
Drott, Ulrich
Delbrueck, Christiane
Bauhammer, Jutta
Cagnotto, Giovanni
Vancheri, Carlo
Sambataro, Gianluca
De Langhe, Ellen
Sainaghi, Pier Paolo
Monti, Cristina
Gigli Berzolari, Francesca
Romano, Mariaeva
Bonella, Francesco
Specker, Christof
Schwarting, Andreas
Villa Blanco, Ignacio
Selmi, Carlo
Ceribelli, Angela
Nuno, Laura
Mera-Varela, Antonio
Perez Gomez, Nair
Fusaro, Enrico
Parisi, Simone
Sinigaglia, Luigi
Del Papa, Nicoletta
Benucci, Maurizio
Cimmino, Marco Amedeo
Riccieri, Valeria
Conti, Fabrizio
Sebastiani, Gian Domenico
Iuliano, Annamaria
Emmi, Giacomo
Cammelli, Daniele
Sebastiani, Marco
Manfredi, Andreina
Bachiller-Corral, Javier
Sifuentes Giraldo, Walter Alberto
Paolazzi, Giuseppe
Saketkoo, Lesley Ann
Giorgi, Roberto
Salaffi, Fausto
Cifrian, Jose
Caporali, Roberto
Locatelli, Francesco
Marchioni, Enrico
Pesci, Alberto
Dei, Giulia
Pozzi, Maria Rosa
Claudia, Lomater
Distler, Jorg
Knitza, Johannes
Schett, George
Iannone, Florenzo
Fornaro, Marco
Franceschini, Franco
Quartuccio, Luca
Gerli, Roberto
Bartoloni, Elena
Bellando Randone, Silvia
Zampogna, Giuseppe
Gonzalez Perez, Montserrat I.
Mejia, Mayra
Vicente, Esther
Triantafyllias, Konstantinos
Lopez-Mejias, Raquel
Matucci-Cerinic, Marco
Selva-O’Callaghan, Albert
Castañeda, Santos
Montecucco, Carlomaurizio
Gonzalez-Gay, Miguel Angel
author_sort Cavagna, Lorenzo
collection PubMed
description Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.
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spelling pubmed-69124902020-01-02 Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course Cavagna, Lorenzo Trallero-Araguás, Ernesto Meloni, Federica Cavazzana, Ilaria Rojas-Serrano, Jorge Feist, Eugen Zanframundo, Giovanni Morandi, Valentina Meyer, Alain Pereira da Silva, Jose Antonio Matos Costa, Carlo Jorge Molberg, Oyvind Andersson, Helena Codullo, Veronica Mosca, Marta Barsotti, Simone Neri, Rossella Scirè, Carlo Govoni, Marcello Furini, Federica Lopez-Longo, Francisco Javier Martinez-Barrio, Julia Schneider, Udo Lorenz, Hanns-Martin Doria, Andrea Ghirardello, Anna Ortego-Centeno, Norberto Confalonieri, Marco Tomietto, Paola Pipitone, Nicolò Rodriguez Cambron, Ana Belen Blázquez Cañamero, María Ángeles Voll, Reinhard Edmund Wendel, Sarah Scarpato, Salvatore Maurier, Francois Limonta, Massimiliano Colombelli, Paolo Giannini, Margherita Geny, Bernard Arrigoni, Eugenio Bravi, Elena Migliorini, Paola Mathieu, Alessandro Piga, Matteo Drott, Ulrich Delbrueck, Christiane Bauhammer, Jutta Cagnotto, Giovanni Vancheri, Carlo Sambataro, Gianluca De Langhe, Ellen Sainaghi, Pier Paolo Monti, Cristina Gigli Berzolari, Francesca Romano, Mariaeva Bonella, Francesco Specker, Christof Schwarting, Andreas Villa Blanco, Ignacio Selmi, Carlo Ceribelli, Angela Nuno, Laura Mera-Varela, Antonio Perez Gomez, Nair Fusaro, Enrico Parisi, Simone Sinigaglia, Luigi Del Papa, Nicoletta Benucci, Maurizio Cimmino, Marco Amedeo Riccieri, Valeria Conti, Fabrizio Sebastiani, Gian Domenico Iuliano, Annamaria Emmi, Giacomo Cammelli, Daniele Sebastiani, Marco Manfredi, Andreina Bachiller-Corral, Javier Sifuentes Giraldo, Walter Alberto Paolazzi, Giuseppe Saketkoo, Lesley Ann Giorgi, Roberto Salaffi, Fausto Cifrian, Jose Caporali, Roberto Locatelli, Francesco Marchioni, Enrico Pesci, Alberto Dei, Giulia Pozzi, Maria Rosa Claudia, Lomater Distler, Jorg Knitza, Johannes Schett, George Iannone, Florenzo Fornaro, Marco Franceschini, Franco Quartuccio, Luca Gerli, Roberto Bartoloni, Elena Bellando Randone, Silvia Zampogna, Giuseppe Gonzalez Perez, Montserrat I. Mejia, Mayra Vicente, Esther Triantafyllias, Konstantinos Lopez-Mejias, Raquel Matucci-Cerinic, Marco Selva-O’Callaghan, Albert Castañeda, Santos Montecucco, Carlomaurizio Gonzalez-Gay, Miguel Angel J Clin Med Article Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition. MDPI 2019-11-18 /pmc/articles/PMC6912490/ /pubmed/31752231 http://dx.doi.org/10.3390/jcm8112013 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cavagna, Lorenzo
Trallero-Araguás, Ernesto
Meloni, Federica
Cavazzana, Ilaria
Rojas-Serrano, Jorge
Feist, Eugen
Zanframundo, Giovanni
Morandi, Valentina
Meyer, Alain
Pereira da Silva, Jose Antonio
Matos Costa, Carlo Jorge
Molberg, Oyvind
Andersson, Helena
Codullo, Veronica
Mosca, Marta
Barsotti, Simone
Neri, Rossella
Scirè, Carlo
Govoni, Marcello
Furini, Federica
Lopez-Longo, Francisco Javier
Martinez-Barrio, Julia
Schneider, Udo
Lorenz, Hanns-Martin
Doria, Andrea
Ghirardello, Anna
Ortego-Centeno, Norberto
Confalonieri, Marco
Tomietto, Paola
Pipitone, Nicolò
Rodriguez Cambron, Ana Belen
Blázquez Cañamero, María Ángeles
Voll, Reinhard Edmund
Wendel, Sarah
Scarpato, Salvatore
Maurier, Francois
Limonta, Massimiliano
Colombelli, Paolo
Giannini, Margherita
Geny, Bernard
Arrigoni, Eugenio
Bravi, Elena
Migliorini, Paola
Mathieu, Alessandro
Piga, Matteo
Drott, Ulrich
Delbrueck, Christiane
Bauhammer, Jutta
Cagnotto, Giovanni
Vancheri, Carlo
Sambataro, Gianluca
De Langhe, Ellen
Sainaghi, Pier Paolo
Monti, Cristina
Gigli Berzolari, Francesca
Romano, Mariaeva
Bonella, Francesco
Specker, Christof
Schwarting, Andreas
Villa Blanco, Ignacio
Selmi, Carlo
Ceribelli, Angela
Nuno, Laura
Mera-Varela, Antonio
Perez Gomez, Nair
Fusaro, Enrico
Parisi, Simone
Sinigaglia, Luigi
Del Papa, Nicoletta
Benucci, Maurizio
Cimmino, Marco Amedeo
Riccieri, Valeria
Conti, Fabrizio
Sebastiani, Gian Domenico
Iuliano, Annamaria
Emmi, Giacomo
Cammelli, Daniele
Sebastiani, Marco
Manfredi, Andreina
Bachiller-Corral, Javier
Sifuentes Giraldo, Walter Alberto
Paolazzi, Giuseppe
Saketkoo, Lesley Ann
Giorgi, Roberto
Salaffi, Fausto
Cifrian, Jose
Caporali, Roberto
Locatelli, Francesco
Marchioni, Enrico
Pesci, Alberto
Dei, Giulia
Pozzi, Maria Rosa
Claudia, Lomater
Distler, Jorg
Knitza, Johannes
Schett, George
Iannone, Florenzo
Fornaro, Marco
Franceschini, Franco
Quartuccio, Luca
Gerli, Roberto
Bartoloni, Elena
Bellando Randone, Silvia
Zampogna, Giuseppe
Gonzalez Perez, Montserrat I.
Mejia, Mayra
Vicente, Esther
Triantafyllias, Konstantinos
Lopez-Mejias, Raquel
Matucci-Cerinic, Marco
Selva-O’Callaghan, Albert
Castañeda, Santos
Montecucco, Carlomaurizio
Gonzalez-Gay, Miguel Angel
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
title Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
title_full Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
title_fullStr Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
title_full_unstemmed Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
title_short Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
title_sort influence of antisynthetase antibodies specificities on antisynthetase syndrome clinical spectrum time course
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912490/
https://www.ncbi.nlm.nih.gov/pubmed/31752231
http://dx.doi.org/10.3390/jcm8112013
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AT iulianoannamaria influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT emmigiacomo influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT cammellidaniele influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT sebastianimarco influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT manfrediandreina influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT bachillercorraljavier influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT sifuentesgiraldowalteralberto influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT paolazzigiuseppe influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT saketkoolesleyann influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT giorgiroberto influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT salaffifausto influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT cifrianjose influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT caporaliroberto influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT locatellifrancesco influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT marchionienrico influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT pescialberto influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT deigiulia influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT pozzimariarosa influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT claudialomater influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT distlerjorg influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT knitzajohannes influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT schettgeorge influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT iannoneflorenzo influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT fornaromarco influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT franceschinifranco influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT quartuccioluca influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT gerliroberto influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT bartolonielena influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT bellandorandonesilvia influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT zampognagiuseppe influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT gonzalezperezmontserrati influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT mejiamayra influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT vicenteesther influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT triantafylliaskonstantinos influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT lopezmejiasraquel influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT matuccicerinicmarco influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT selvaocallaghanalbert influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT castanedasantos influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT montecuccocarlomaurizio influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse
AT gonzalezgaymiguelangel influenceofantisynthetaseantibodiesspecificitiesonantisynthetasesyndromeclinicalspectrumtimecourse