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Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS)....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912490/ https://www.ncbi.nlm.nih.gov/pubmed/31752231 http://dx.doi.org/10.3390/jcm8112013 |
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author | Cavagna, Lorenzo Trallero-Araguás, Ernesto Meloni, Federica Cavazzana, Ilaria Rojas-Serrano, Jorge Feist, Eugen Zanframundo, Giovanni Morandi, Valentina Meyer, Alain Pereira da Silva, Jose Antonio Matos Costa, Carlo Jorge Molberg, Oyvind Andersson, Helena Codullo, Veronica Mosca, Marta Barsotti, Simone Neri, Rossella Scirè, Carlo Govoni, Marcello Furini, Federica Lopez-Longo, Francisco Javier Martinez-Barrio, Julia Schneider, Udo Lorenz, Hanns-Martin Doria, Andrea Ghirardello, Anna Ortego-Centeno, Norberto Confalonieri, Marco Tomietto, Paola Pipitone, Nicolò Rodriguez Cambron, Ana Belen Blázquez Cañamero, María Ángeles Voll, Reinhard Edmund Wendel, Sarah Scarpato, Salvatore Maurier, Francois Limonta, Massimiliano Colombelli, Paolo Giannini, Margherita Geny, Bernard Arrigoni, Eugenio Bravi, Elena Migliorini, Paola Mathieu, Alessandro Piga, Matteo Drott, Ulrich Delbrueck, Christiane Bauhammer, Jutta Cagnotto, Giovanni Vancheri, Carlo Sambataro, Gianluca De Langhe, Ellen Sainaghi, Pier Paolo Monti, Cristina Gigli Berzolari, Francesca Romano, Mariaeva Bonella, Francesco Specker, Christof Schwarting, Andreas Villa Blanco, Ignacio Selmi, Carlo Ceribelli, Angela Nuno, Laura Mera-Varela, Antonio Perez Gomez, Nair Fusaro, Enrico Parisi, Simone Sinigaglia, Luigi Del Papa, Nicoletta Benucci, Maurizio Cimmino, Marco Amedeo Riccieri, Valeria Conti, Fabrizio Sebastiani, Gian Domenico Iuliano, Annamaria Emmi, Giacomo Cammelli, Daniele Sebastiani, Marco Manfredi, Andreina Bachiller-Corral, Javier Sifuentes Giraldo, Walter Alberto Paolazzi, Giuseppe Saketkoo, Lesley Ann Giorgi, Roberto Salaffi, Fausto Cifrian, Jose Caporali, Roberto Locatelli, Francesco Marchioni, Enrico Pesci, Alberto Dei, Giulia Pozzi, Maria Rosa Claudia, Lomater Distler, Jorg Knitza, Johannes Schett, George Iannone, Florenzo Fornaro, Marco Franceschini, Franco Quartuccio, Luca Gerli, Roberto Bartoloni, Elena Bellando Randone, Silvia Zampogna, Giuseppe Gonzalez Perez, Montserrat I. Mejia, Mayra Vicente, Esther Triantafyllias, Konstantinos Lopez-Mejias, Raquel Matucci-Cerinic, Marco Selva-O’Callaghan, Albert Castañeda, Santos Montecucco, Carlomaurizio Gonzalez-Gay, Miguel Angel |
author_facet | Cavagna, Lorenzo Trallero-Araguás, Ernesto Meloni, Federica Cavazzana, Ilaria Rojas-Serrano, Jorge Feist, Eugen Zanframundo, Giovanni Morandi, Valentina Meyer, Alain Pereira da Silva, Jose Antonio Matos Costa, Carlo Jorge Molberg, Oyvind Andersson, Helena Codullo, Veronica Mosca, Marta Barsotti, Simone Neri, Rossella Scirè, Carlo Govoni, Marcello Furini, Federica Lopez-Longo, Francisco Javier Martinez-Barrio, Julia Schneider, Udo Lorenz, Hanns-Martin Doria, Andrea Ghirardello, Anna Ortego-Centeno, Norberto Confalonieri, Marco Tomietto, Paola Pipitone, Nicolò Rodriguez Cambron, Ana Belen Blázquez Cañamero, María Ángeles Voll, Reinhard Edmund Wendel, Sarah Scarpato, Salvatore Maurier, Francois Limonta, Massimiliano Colombelli, Paolo Giannini, Margherita Geny, Bernard Arrigoni, Eugenio Bravi, Elena Migliorini, Paola Mathieu, Alessandro Piga, Matteo Drott, Ulrich Delbrueck, Christiane Bauhammer, Jutta Cagnotto, Giovanni Vancheri, Carlo Sambataro, Gianluca De Langhe, Ellen Sainaghi, Pier Paolo Monti, Cristina Gigli Berzolari, Francesca Romano, Mariaeva Bonella, Francesco Specker, Christof Schwarting, Andreas Villa Blanco, Ignacio Selmi, Carlo Ceribelli, Angela Nuno, Laura Mera-Varela, Antonio Perez Gomez, Nair Fusaro, Enrico Parisi, Simone Sinigaglia, Luigi Del Papa, Nicoletta Benucci, Maurizio Cimmino, Marco Amedeo Riccieri, Valeria Conti, Fabrizio Sebastiani, Gian Domenico Iuliano, Annamaria Emmi, Giacomo Cammelli, Daniele Sebastiani, Marco Manfredi, Andreina Bachiller-Corral, Javier Sifuentes Giraldo, Walter Alberto Paolazzi, Giuseppe Saketkoo, Lesley Ann Giorgi, Roberto Salaffi, Fausto Cifrian, Jose Caporali, Roberto Locatelli, Francesco Marchioni, Enrico Pesci, Alberto Dei, Giulia Pozzi, Maria Rosa Claudia, Lomater Distler, Jorg Knitza, Johannes Schett, George Iannone, Florenzo Fornaro, Marco Franceschini, Franco Quartuccio, Luca Gerli, Roberto Bartoloni, Elena Bellando Randone, Silvia Zampogna, Giuseppe Gonzalez Perez, Montserrat I. Mejia, Mayra Vicente, Esther Triantafyllias, Konstantinos Lopez-Mejias, Raquel Matucci-Cerinic, Marco Selva-O’Callaghan, Albert Castañeda, Santos Montecucco, Carlomaurizio Gonzalez-Gay, Miguel Angel |
author_sort | Cavagna, Lorenzo |
collection | PubMed |
description | Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition. |
format | Online Article Text |
id | pubmed-6912490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69124902020-01-02 Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course Cavagna, Lorenzo Trallero-Araguás, Ernesto Meloni, Federica Cavazzana, Ilaria Rojas-Serrano, Jorge Feist, Eugen Zanframundo, Giovanni Morandi, Valentina Meyer, Alain Pereira da Silva, Jose Antonio Matos Costa, Carlo Jorge Molberg, Oyvind Andersson, Helena Codullo, Veronica Mosca, Marta Barsotti, Simone Neri, Rossella Scirè, Carlo Govoni, Marcello Furini, Federica Lopez-Longo, Francisco Javier Martinez-Barrio, Julia Schneider, Udo Lorenz, Hanns-Martin Doria, Andrea Ghirardello, Anna Ortego-Centeno, Norberto Confalonieri, Marco Tomietto, Paola Pipitone, Nicolò Rodriguez Cambron, Ana Belen Blázquez Cañamero, María Ángeles Voll, Reinhard Edmund Wendel, Sarah Scarpato, Salvatore Maurier, Francois Limonta, Massimiliano Colombelli, Paolo Giannini, Margherita Geny, Bernard Arrigoni, Eugenio Bravi, Elena Migliorini, Paola Mathieu, Alessandro Piga, Matteo Drott, Ulrich Delbrueck, Christiane Bauhammer, Jutta Cagnotto, Giovanni Vancheri, Carlo Sambataro, Gianluca De Langhe, Ellen Sainaghi, Pier Paolo Monti, Cristina Gigli Berzolari, Francesca Romano, Mariaeva Bonella, Francesco Specker, Christof Schwarting, Andreas Villa Blanco, Ignacio Selmi, Carlo Ceribelli, Angela Nuno, Laura Mera-Varela, Antonio Perez Gomez, Nair Fusaro, Enrico Parisi, Simone Sinigaglia, Luigi Del Papa, Nicoletta Benucci, Maurizio Cimmino, Marco Amedeo Riccieri, Valeria Conti, Fabrizio Sebastiani, Gian Domenico Iuliano, Annamaria Emmi, Giacomo Cammelli, Daniele Sebastiani, Marco Manfredi, Andreina Bachiller-Corral, Javier Sifuentes Giraldo, Walter Alberto Paolazzi, Giuseppe Saketkoo, Lesley Ann Giorgi, Roberto Salaffi, Fausto Cifrian, Jose Caporali, Roberto Locatelli, Francesco Marchioni, Enrico Pesci, Alberto Dei, Giulia Pozzi, Maria Rosa Claudia, Lomater Distler, Jorg Knitza, Johannes Schett, George Iannone, Florenzo Fornaro, Marco Franceschini, Franco Quartuccio, Luca Gerli, Roberto Bartoloni, Elena Bellando Randone, Silvia Zampogna, Giuseppe Gonzalez Perez, Montserrat I. Mejia, Mayra Vicente, Esther Triantafyllias, Konstantinos Lopez-Mejias, Raquel Matucci-Cerinic, Marco Selva-O’Callaghan, Albert Castañeda, Santos Montecucco, Carlomaurizio Gonzalez-Gay, Miguel Angel J Clin Med Article Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition. MDPI 2019-11-18 /pmc/articles/PMC6912490/ /pubmed/31752231 http://dx.doi.org/10.3390/jcm8112013 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cavagna, Lorenzo Trallero-Araguás, Ernesto Meloni, Federica Cavazzana, Ilaria Rojas-Serrano, Jorge Feist, Eugen Zanframundo, Giovanni Morandi, Valentina Meyer, Alain Pereira da Silva, Jose Antonio Matos Costa, Carlo Jorge Molberg, Oyvind Andersson, Helena Codullo, Veronica Mosca, Marta Barsotti, Simone Neri, Rossella Scirè, Carlo Govoni, Marcello Furini, Federica Lopez-Longo, Francisco Javier Martinez-Barrio, Julia Schneider, Udo Lorenz, Hanns-Martin Doria, Andrea Ghirardello, Anna Ortego-Centeno, Norberto Confalonieri, Marco Tomietto, Paola Pipitone, Nicolò Rodriguez Cambron, Ana Belen Blázquez Cañamero, María Ángeles Voll, Reinhard Edmund Wendel, Sarah Scarpato, Salvatore Maurier, Francois Limonta, Massimiliano Colombelli, Paolo Giannini, Margherita Geny, Bernard Arrigoni, Eugenio Bravi, Elena Migliorini, Paola Mathieu, Alessandro Piga, Matteo Drott, Ulrich Delbrueck, Christiane Bauhammer, Jutta Cagnotto, Giovanni Vancheri, Carlo Sambataro, Gianluca De Langhe, Ellen Sainaghi, Pier Paolo Monti, Cristina Gigli Berzolari, Francesca Romano, Mariaeva Bonella, Francesco Specker, Christof Schwarting, Andreas Villa Blanco, Ignacio Selmi, Carlo Ceribelli, Angela Nuno, Laura Mera-Varela, Antonio Perez Gomez, Nair Fusaro, Enrico Parisi, Simone Sinigaglia, Luigi Del Papa, Nicoletta Benucci, Maurizio Cimmino, Marco Amedeo Riccieri, Valeria Conti, Fabrizio Sebastiani, Gian Domenico Iuliano, Annamaria Emmi, Giacomo Cammelli, Daniele Sebastiani, Marco Manfredi, Andreina Bachiller-Corral, Javier Sifuentes Giraldo, Walter Alberto Paolazzi, Giuseppe Saketkoo, Lesley Ann Giorgi, Roberto Salaffi, Fausto Cifrian, Jose Caporali, Roberto Locatelli, Francesco Marchioni, Enrico Pesci, Alberto Dei, Giulia Pozzi, Maria Rosa Claudia, Lomater Distler, Jorg Knitza, Johannes Schett, George Iannone, Florenzo Fornaro, Marco Franceschini, Franco Quartuccio, Luca Gerli, Roberto Bartoloni, Elena Bellando Randone, Silvia Zampogna, Giuseppe Gonzalez Perez, Montserrat I. Mejia, Mayra Vicente, Esther Triantafyllias, Konstantinos Lopez-Mejias, Raquel Matucci-Cerinic, Marco Selva-O’Callaghan, Albert Castañeda, Santos Montecucco, Carlomaurizio Gonzalez-Gay, Miguel Angel Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title | Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_full | Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_fullStr | Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_full_unstemmed | Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_short | Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course |
title_sort | influence of antisynthetase antibodies specificities on antisynthetase syndrome clinical spectrum time course |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912490/ https://www.ncbi.nlm.nih.gov/pubmed/31752231 http://dx.doi.org/10.3390/jcm8112013 |
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