Cargando…

ACVR1 Function in Health and Disease

Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valer, José Antonio, Sánchez-de-Diego, Cristina, Pimenta-Lopes, Carolina, Rosa, Jose Luis, Ventura, Francesc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912516/ https://www.ncbi.nlm.nih.gov/pubmed/31683698 http://dx.doi.org/10.3390/cells8111366

Ejemplares similares

Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
por: Sánchez-de-Diego, Cristina, et al.
Publicado: (2019)

NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression
por: Sánchez-de-Diego, Cristina, et al.
Publicado: (2020)

HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling
por: Pedrazza, Leonardo, et al.
Publicado: (2023)

Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program
por: Sánchez-de-Diego, Cristina, et al.
Publicado: (2019)

Inhibition of phosphatidylinositol 3‐kinase α (PI3Kα) prevents heterotopic ossification
por: Valer, José Antonio, et al.
Publicado: (2019)

Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes)
por: Trumpp, Michael, et al.
Publicado: (2023)

Genomic Context and Mechanisms of the ACVR1 Mutation in Fibrodysplasia Ossificans Progressiva
por: Ravazzolo, Roberto, et al.
Publicado: (2021)

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
por: Olsen, Oddrun Elise, et al.
Publicado: (2015)

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
por: Aykul, Senem, et al.
Publicado: (2022)

The effect of ACVR1B/TGFBR1/ACVR1C signaling inhibition on oocyte and granulosa cell development during in vitro growth culture
por: AKIMOTO, Yuki, et al.
Publicado: (2023)

ACVR1 mutation and Fibrodysplasia Ossificans Progressiva in Chinese children
por: Ho, Assunta CH, et al.
Publicado: (2011)

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
por: Taylor, Kathryn R, et al.
Publicado: (2014)

Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva
por: Giacopelli, Francesca, et al.
Publicado: (2013)

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas
por: Fortin, Jerome, et al.
Publicado: (2020)

Non-additive effects of ACVR2A in preeclampsia in a Philippine population
por: Amosco, Melissa D., et al.
Publicado: (2019)

ACVR1 Gene Mutation in Sporadic Korean Patients with Fibrodysplasia Ossificans Progressiva
por: Lee, Dong Yeon, et al.
Publicado: (2009)

MicroRNA-384 inhibits the progression of breast cancer by targeting ACVR1
por: Wang, Yongxia, et al.
Publicado: (2018)

ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma
por: Asnaghi, Laura, et al.
Publicado: (2018)

Activation of AcvR1-Mediated Signaling Results in Semilunar Valve Defects
por: Syed, Shabber, et al.
Publicado: (2022)

The Role of the 3′UTR Region in the Regulation of the ACVR1/Alk-2 Gene Expression
por: Mura, Marzia, et al.
Publicado: (2012)

Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish
por: Allen, Robyn S, et al.
Publicado: (2020)

ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans
por: Yu, Xiaobing, et al.
Publicado: (2023)

Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis
por: Oh, Stephen T., et al.
Publicado: (2023)

High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva
por: Cappato, Serena, et al.
Publicado: (2016)

Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken
por: Bhattacharya, T. K., et al.
Publicado: (2019)

Correction: High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva
por: Cappato, Serena, et al.
Publicado: (2016)

Novel Mutations in ACVR1 Result in Atypical Features in Two Fibrodysplasia Ossificans Progressiva Patients
por: Petrie, Kirsten A., et al.
Publicado: (2009)

Deficient Signaling via Alk2 (Acvr1) Leads to Bicuspid Aortic Valve Development
por: Thomas, Penny S., et al.
Publicado: (2012)

Regulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare
por: da Silveira, Juliano C, et al.
Publicado: (2014)

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma
por: Carvalho, Diana M., et al.
Publicado: (2022)

A case of Fibrodysplasia Ossificans Progressiva associated with a novel variant of the ACVR1 gene
por: Cappato, Serena, et al.
Publicado: (2021)

The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans
por: Zhang, Xianpeng, et al.
Publicado: (2021)

Modeling the ACVR1(R206H) mutation in human skeletal muscle stem cells
por: Barruet, Emilie, et al.
Publicado: (2021)

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration
por: Hillege, Michèle MG, et al.
Publicado: (2022)

Does the expression of the ACVR2A gene affect the development of colorectal cancer?
por: Wodziński, Damian, et al.
Publicado: (2019)

Momelotinib (JAK1/JAK2/ACVR1 inhibitor): mechanism of action, clinical trial reports, and therapeutic prospects beyond myelofibrosis
por: Tefferi, Ayalew, et al.
Publicado: (2023)

The p38α MAPK Function in Osteoprecursors Is Required for Bone Formation and Bone Homeostasis in Adult Mice
por: Rodríguez-Carballo, Edgardo, et al.
Publicado: (2014)

Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer
por: Nie, Yuanyuan, et al.
Publicado: (2019)

Pathogenic ACVR1(R206H) activation by Activin A‐induced receptor clustering and autophosphorylation
por: Ramachandran, Anassuya, et al.
Publicado: (2021)

DIPG-51. ACVR1 MUTATIONS PROMOTE TUMOR GROWTH IN MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA
por: Adorno, Jennifer Ocasio, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4m0j4duhnj44p98ub0amt9mdd1