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Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study

Background: Autoimmune atrophic gastritis (AAG) leads to iron and/or vitamin B12 malabsorption, with subsequent haematological alterations which could represent the sole clinical manifestation. We aimed to assess patterns of anaemia and micronutrient deficiencies in patients with AAG at the time of...

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Autores principales: Lenti, Marco Vincenzo, Lahner, Edith, Bergamaschi, Gaetano, Miceli, Emanuela, Conti, Laura, Massironi, Sara, Cococcia, Sara, Zilli, Alessandra, Caprioli, Flavio, Vecchi, Maurizio, Maiero, Stefania, Cannizzaro, Renato, Corazza, Gino Roberto, Annibale, Bruno, Di Sabatino, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912578/
https://www.ncbi.nlm.nih.gov/pubmed/31731715
http://dx.doi.org/10.3390/jcm8111992
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author Lenti, Marco Vincenzo
Lahner, Edith
Bergamaschi, Gaetano
Miceli, Emanuela
Conti, Laura
Massironi, Sara
Cococcia, Sara
Zilli, Alessandra
Caprioli, Flavio
Vecchi, Maurizio
Maiero, Stefania
Cannizzaro, Renato
Corazza, Gino Roberto
Annibale, Bruno
Di Sabatino, Antonio
author_facet Lenti, Marco Vincenzo
Lahner, Edith
Bergamaschi, Gaetano
Miceli, Emanuela
Conti, Laura
Massironi, Sara
Cococcia, Sara
Zilli, Alessandra
Caprioli, Flavio
Vecchi, Maurizio
Maiero, Stefania
Cannizzaro, Renato
Corazza, Gino Roberto
Annibale, Bruno
Di Sabatino, Antonio
author_sort Lenti, Marco Vincenzo
collection PubMed
description Background: Autoimmune atrophic gastritis (AAG) leads to iron and/or vitamin B12 malabsorption, with subsequent haematological alterations which could represent the sole clinical manifestation. We aimed to assess patterns of anaemia and micronutrient deficiencies in patients with AAG at the time of diagnosis. Methods: Observational, multicentre, cross-sectional study including consecutive adult patients diagnosed with AAG within the last ten years. Cell blood count, red cell distribution width, serum vitamin B12, and ferritin were collected. Multivariate analysis for predictive factors of anaemia was computed. Results: 654 AAG patients (mean age 59.2 ± 13.8 years, female (F): male (M) ratio = 2.3:1) were included. Anaemia was present in 316 patients (48.3%; mean age 60.1 ± 15.8 years, F:M ratio = 2.3:1). Pernicious anaemia (132/316 cases, 41.7%) was more common in males (27.1% versus 12.4%; p = 0.001) and in older patients (63.0 ± 14.6 versus 58.9 ± 14.9 years; p = 0.014), while iron deficiency anaemia (112/316 cases, 35.4%) was more common in females (16.9% versus 10.0%; p = 0.039) and in younger patients (56.8 ± 16.6 versus 60.2 ± 14.6 years; p = 0.043). The prevalence of iron deficiency was equally distributed between anaemic and non-anaemic patients (p = 0.9). Anisocytosis (odds ratio: 10.65, 95% confidence interval: 6.13–18.50, p < 0.0001) was independently associated with anaemia. Conclusions: Anaemia is a common manifestation in AAG patients, mostly due to micronutrient deficiencies. Scant haematologic alterations and micronutrient deficiencies may precede overt anaemia.
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spelling pubmed-69125782020-01-02 Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study Lenti, Marco Vincenzo Lahner, Edith Bergamaschi, Gaetano Miceli, Emanuela Conti, Laura Massironi, Sara Cococcia, Sara Zilli, Alessandra Caprioli, Flavio Vecchi, Maurizio Maiero, Stefania Cannizzaro, Renato Corazza, Gino Roberto Annibale, Bruno Di Sabatino, Antonio J Clin Med Article Background: Autoimmune atrophic gastritis (AAG) leads to iron and/or vitamin B12 malabsorption, with subsequent haematological alterations which could represent the sole clinical manifestation. We aimed to assess patterns of anaemia and micronutrient deficiencies in patients with AAG at the time of diagnosis. Methods: Observational, multicentre, cross-sectional study including consecutive adult patients diagnosed with AAG within the last ten years. Cell blood count, red cell distribution width, serum vitamin B12, and ferritin were collected. Multivariate analysis for predictive factors of anaemia was computed. Results: 654 AAG patients (mean age 59.2 ± 13.8 years, female (F): male (M) ratio = 2.3:1) were included. Anaemia was present in 316 patients (48.3%; mean age 60.1 ± 15.8 years, F:M ratio = 2.3:1). Pernicious anaemia (132/316 cases, 41.7%) was more common in males (27.1% versus 12.4%; p = 0.001) and in older patients (63.0 ± 14.6 versus 58.9 ± 14.9 years; p = 0.014), while iron deficiency anaemia (112/316 cases, 35.4%) was more common in females (16.9% versus 10.0%; p = 0.039) and in younger patients (56.8 ± 16.6 versus 60.2 ± 14.6 years; p = 0.043). The prevalence of iron deficiency was equally distributed between anaemic and non-anaemic patients (p = 0.9). Anisocytosis (odds ratio: 10.65, 95% confidence interval: 6.13–18.50, p < 0.0001) was independently associated with anaemia. Conclusions: Anaemia is a common manifestation in AAG patients, mostly due to micronutrient deficiencies. Scant haematologic alterations and micronutrient deficiencies may precede overt anaemia. MDPI 2019-11-15 /pmc/articles/PMC6912578/ /pubmed/31731715 http://dx.doi.org/10.3390/jcm8111992 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lenti, Marco Vincenzo
Lahner, Edith
Bergamaschi, Gaetano
Miceli, Emanuela
Conti, Laura
Massironi, Sara
Cococcia, Sara
Zilli, Alessandra
Caprioli, Flavio
Vecchi, Maurizio
Maiero, Stefania
Cannizzaro, Renato
Corazza, Gino Roberto
Annibale, Bruno
Di Sabatino, Antonio
Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study
title Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study
title_full Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study
title_fullStr Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study
title_full_unstemmed Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study
title_short Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study
title_sort cell blood count alterations and patterns of anaemia in autoimmune atrophic gastritis at diagnosis: a multicentre study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912578/
https://www.ncbi.nlm.nih.gov/pubmed/31731715
http://dx.doi.org/10.3390/jcm8111992
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