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Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults

Peak expiratory flow (PEF) has been linked to several health-related outcomes in older people, but its association with frailty is still unclear. This study investigates the association between PEF and prevalent and incident frailty in older adults. Data come from 2559 community-dwelling participant...

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Autores principales: Trevisan, Caterina, Rizzuto, Debora, Maggi, Stefania, Sergi, Giuseppe, Welmer, Anna-Karin, Vetrano, Davide Liborio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912606/
https://www.ncbi.nlm.nih.gov/pubmed/31703301
http://dx.doi.org/10.3390/jcm8111901
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author Trevisan, Caterina
Rizzuto, Debora
Maggi, Stefania
Sergi, Giuseppe
Welmer, Anna-Karin
Vetrano, Davide Liborio
author_facet Trevisan, Caterina
Rizzuto, Debora
Maggi, Stefania
Sergi, Giuseppe
Welmer, Anna-Karin
Vetrano, Davide Liborio
author_sort Trevisan, Caterina
collection PubMed
description Peak expiratory flow (PEF) has been linked to several health-related outcomes in older people, but its association with frailty is still unclear. This study investigates the association between PEF and prevalent and incident frailty in older adults. Data come from 2559 community-dwelling participants (age ≥ 60 years) of the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Baseline PEF was expressed as standardized residual (SR) percentiles. Frailty was assessed at baseline and over six years, according to the Fried criteria. Associations between PEF and frailty were estimated cross-sectionally through logistic regressions, and longitudinally by multinomial logistic regression, considering death as alternative outcome. Obstructive respiratory diseases and smoking habits were treated as potential effect modifiers. Our cross-sectional results showed that the 10th–49th and <10th PEF SR percentile categories were associated with three- and five-fold higher likelihood of being frail than the 80th–100th category. Similar estimates were confirmed longitudinally, i.e., adjusted OR = 3.11 (95% CI: 1.61–6.01) for PEF SR percentiles < 10th, compared with 80th–100th percentiles. Associations were enounced in participants without physical deficits, and tended to be stronger among those with baseline obstructive respiratory diseases, and, longitudinally, also among former/current smokers. These findings suggest that PEF is a marker of general robustness in older adults, and its reduction exceeding that expected by age is associated with frailty development.
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spelling pubmed-69126062020-01-02 Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults Trevisan, Caterina Rizzuto, Debora Maggi, Stefania Sergi, Giuseppe Welmer, Anna-Karin Vetrano, Davide Liborio J Clin Med Article Peak expiratory flow (PEF) has been linked to several health-related outcomes in older people, but its association with frailty is still unclear. This study investigates the association between PEF and prevalent and incident frailty in older adults. Data come from 2559 community-dwelling participants (age ≥ 60 years) of the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Baseline PEF was expressed as standardized residual (SR) percentiles. Frailty was assessed at baseline and over six years, according to the Fried criteria. Associations between PEF and frailty were estimated cross-sectionally through logistic regressions, and longitudinally by multinomial logistic regression, considering death as alternative outcome. Obstructive respiratory diseases and smoking habits were treated as potential effect modifiers. Our cross-sectional results showed that the 10th–49th and <10th PEF SR percentile categories were associated with three- and five-fold higher likelihood of being frail than the 80th–100th category. Similar estimates were confirmed longitudinally, i.e., adjusted OR = 3.11 (95% CI: 1.61–6.01) for PEF SR percentiles < 10th, compared with 80th–100th percentiles. Associations were enounced in participants without physical deficits, and tended to be stronger among those with baseline obstructive respiratory diseases, and, longitudinally, also among former/current smokers. These findings suggest that PEF is a marker of general robustness in older adults, and its reduction exceeding that expected by age is associated with frailty development. MDPI 2019-11-07 /pmc/articles/PMC6912606/ /pubmed/31703301 http://dx.doi.org/10.3390/jcm8111901 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trevisan, Caterina
Rizzuto, Debora
Maggi, Stefania
Sergi, Giuseppe
Welmer, Anna-Karin
Vetrano, Davide Liborio
Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults
title Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults
title_full Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults
title_fullStr Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults
title_full_unstemmed Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults
title_short Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults
title_sort cross-sectional and longitudinal associations between peak expiratory flow and frailty in older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912606/
https://www.ncbi.nlm.nih.gov/pubmed/31703301
http://dx.doi.org/10.3390/jcm8111901
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