Cargando…
Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review
Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formatio...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912614/ https://www.ncbi.nlm.nih.gov/pubmed/31731704 http://dx.doi.org/10.3390/antiox8110556 |
_version_ | 1783479497508519936 |
---|---|
author | Rong, Fan Tang, Yizhang Wang, Tengjiao Feng, Tao Song, Jiang Li, Peng Huang, Wei |
author_facet | Rong, Fan Tang, Yizhang Wang, Tengjiao Feng, Tao Song, Jiang Li, Peng Huang, Wei |
author_sort | Rong, Fan |
collection | PubMed |
description | Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era. |
format | Online Article Text |
id | pubmed-6912614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69126142020-01-02 Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review Rong, Fan Tang, Yizhang Wang, Tengjiao Feng, Tao Song, Jiang Li, Peng Huang, Wei Antioxidants (Basel) Review Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era. MDPI 2019-11-15 /pmc/articles/PMC6912614/ /pubmed/31731704 http://dx.doi.org/10.3390/antiox8110556 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rong, Fan Tang, Yizhang Wang, Tengjiao Feng, Tao Song, Jiang Li, Peng Huang, Wei Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review |
title | Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review |
title_full | Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review |
title_fullStr | Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review |
title_full_unstemmed | Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review |
title_short | Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review |
title_sort | nitric oxide-releasing polymeric materials for antimicrobial applications: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912614/ https://www.ncbi.nlm.nih.gov/pubmed/31731704 http://dx.doi.org/10.3390/antiox8110556 |
work_keys_str_mv | AT rongfan nitricoxidereleasingpolymericmaterialsforantimicrobialapplicationsareview AT tangyizhang nitricoxidereleasingpolymericmaterialsforantimicrobialapplicationsareview AT wangtengjiao nitricoxidereleasingpolymericmaterialsforantimicrobialapplicationsareview AT fengtao nitricoxidereleasingpolymericmaterialsforantimicrobialapplicationsareview AT songjiang nitricoxidereleasingpolymericmaterialsforantimicrobialapplicationsareview AT lipeng nitricoxidereleasingpolymericmaterialsforantimicrobialapplicationsareview AT huangwei nitricoxidereleasingpolymericmaterialsforantimicrobialapplicationsareview |