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Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formatio...

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Autores principales: Rong, Fan, Tang, Yizhang, Wang, Tengjiao, Feng, Tao, Song, Jiang, Li, Peng, Huang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912614/
https://www.ncbi.nlm.nih.gov/pubmed/31731704
http://dx.doi.org/10.3390/antiox8110556
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author Rong, Fan
Tang, Yizhang
Wang, Tengjiao
Feng, Tao
Song, Jiang
Li, Peng
Huang, Wei
author_facet Rong, Fan
Tang, Yizhang
Wang, Tengjiao
Feng, Tao
Song, Jiang
Li, Peng
Huang, Wei
author_sort Rong, Fan
collection PubMed
description Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era.
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spelling pubmed-69126142020-01-02 Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review Rong, Fan Tang, Yizhang Wang, Tengjiao Feng, Tao Song, Jiang Li, Peng Huang, Wei Antioxidants (Basel) Review Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era. MDPI 2019-11-15 /pmc/articles/PMC6912614/ /pubmed/31731704 http://dx.doi.org/10.3390/antiox8110556 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rong, Fan
Tang, Yizhang
Wang, Tengjiao
Feng, Tao
Song, Jiang
Li, Peng
Huang, Wei
Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review
title Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review
title_full Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review
title_fullStr Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review
title_full_unstemmed Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review
title_short Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review
title_sort nitric oxide-releasing polymeric materials for antimicrobial applications: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912614/
https://www.ncbi.nlm.nih.gov/pubmed/31731704
http://dx.doi.org/10.3390/antiox8110556
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