Cargando…
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment options available. Therefore, there is an unmet...
Autores principales: | Simón Serrano, Sonia, Grönberg, Alvar, Longato, Lisa, Rombouts, Krista, Kuo, Joseph, Gregory, Matthew, Moss, Steven, Elmér, Eskil, Mazza, Giuseppe, Gallay, Philippe, Pinzani, Massimo, Hansson, Magnus J., Massoumi, Ramin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912624/ https://www.ncbi.nlm.nih.gov/pubmed/31717385 http://dx.doi.org/10.3390/cells8111409 |
Ejemplares similares
-
Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis
por: Kuo, Joseph, et al.
Publicado: (2019) -
Synergistic Effects of Sanglifehrin-Based Cyclophilin Inhibitor NV651 with Cisplatin in Hepatocellular Carcinoma
por: Simón Serrano, Sonia, et al.
Publicado: (2022) -
Novel Cyclophilin Inhibitor Decreases Cell Proliferation and Tumor Growth in Models of Hepatocellular Carcinoma
por: Simón Serrano, Sonia, et al.
Publicado: (2021) -
Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized-liver mice
por: Bobardt, Michael, et al.
Publicado: (2020) -
Bioengineering and Semisynthesis of an Optimized Cyclophilin Inhibitor for Treatment of Chronic Viral Infection
por: Hansson, Magnus Joakim, et al.
Publicado: (2015)