Cargando…

Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age

Background: Maternal stress during pregnancy can affect fetal development during certain sensitive periods. Objective: To longitudinally assess maternal hair cortisol levels during pregnancy, and the postpartum along with neonatal hair cortisol levels that could be associated with infant neurodevelo...

Descripción completa

Detalles Bibliográficos
Autores principales: Caparros-Gonzalez, Rafael A., Romero-Gonzalez, Borja, Gonzalez-Perez, Raquel, Lucena-Prieto, Lidia, Perez-Garcia, Miguel, Cruz-Quintana, Francisco, Peralta-Ramirez, Maria Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912650/
https://www.ncbi.nlm.nih.gov/pubmed/31752272
http://dx.doi.org/10.3390/jcm8112015
_version_ 1783479506616451072
author Caparros-Gonzalez, Rafael A.
Romero-Gonzalez, Borja
Gonzalez-Perez, Raquel
Lucena-Prieto, Lidia
Perez-Garcia, Miguel
Cruz-Quintana, Francisco
Peralta-Ramirez, Maria Isabel
author_facet Caparros-Gonzalez, Rafael A.
Romero-Gonzalez, Borja
Gonzalez-Perez, Raquel
Lucena-Prieto, Lidia
Perez-Garcia, Miguel
Cruz-Quintana, Francisco
Peralta-Ramirez, Maria Isabel
author_sort Caparros-Gonzalez, Rafael A.
collection PubMed
description Background: Maternal stress during pregnancy can affect fetal development during certain sensitive periods. Objective: To longitudinally assess maternal hair cortisol levels during pregnancy, and the postpartum along with neonatal hair cortisol levels that could be associated with infant neurodevelopment at six months of age. Methods: A sample of 41 pregnant women longitudinally assessed during the first, second, and third trimester and the postpartum, along with their 41 full-term neonates participated in this study. Hair cortisol levels were assessed from participants. Infant neurodevelopment was assessed by means of the Bayley Scale of Infants Development, Third Edition at age six months. Results: Maternal hair cortisol levels in the first and second trimester accounted for 24% and 23%, respectively, of variance of infant gross motor development (p < 0.05). Maternal hair cortisol levels during the postpartum accounted for 31% of variance of infant cognitive development (p < 0.05), and 25% of variance of infant gross motor development (p < 0.05). Neonatal hair cortisol levels accounted for 28% of variance of infant gross motor development (p < 0.05). Conclusions: The preconception and prenatal time are sensitive periods related to infant neurodevelopment along with the cortisol levels surrounding the fetus while in the womb. Pregnant women could be assessed for hair cortisol levels while attending a prenatal appointment.
format Online
Article
Text
id pubmed-6912650
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69126502020-01-02 Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age Caparros-Gonzalez, Rafael A. Romero-Gonzalez, Borja Gonzalez-Perez, Raquel Lucena-Prieto, Lidia Perez-Garcia, Miguel Cruz-Quintana, Francisco Peralta-Ramirez, Maria Isabel J Clin Med Article Background: Maternal stress during pregnancy can affect fetal development during certain sensitive periods. Objective: To longitudinally assess maternal hair cortisol levels during pregnancy, and the postpartum along with neonatal hair cortisol levels that could be associated with infant neurodevelopment at six months of age. Methods: A sample of 41 pregnant women longitudinally assessed during the first, second, and third trimester and the postpartum, along with their 41 full-term neonates participated in this study. Hair cortisol levels were assessed from participants. Infant neurodevelopment was assessed by means of the Bayley Scale of Infants Development, Third Edition at age six months. Results: Maternal hair cortisol levels in the first and second trimester accounted for 24% and 23%, respectively, of variance of infant gross motor development (p < 0.05). Maternal hair cortisol levels during the postpartum accounted for 31% of variance of infant cognitive development (p < 0.05), and 25% of variance of infant gross motor development (p < 0.05). Neonatal hair cortisol levels accounted for 28% of variance of infant gross motor development (p < 0.05). Conclusions: The preconception and prenatal time are sensitive periods related to infant neurodevelopment along with the cortisol levels surrounding the fetus while in the womb. Pregnant women could be assessed for hair cortisol levels while attending a prenatal appointment. MDPI 2019-11-19 /pmc/articles/PMC6912650/ /pubmed/31752272 http://dx.doi.org/10.3390/jcm8112015 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caparros-Gonzalez, Rafael A.
Romero-Gonzalez, Borja
Gonzalez-Perez, Raquel
Lucena-Prieto, Lidia
Perez-Garcia, Miguel
Cruz-Quintana, Francisco
Peralta-Ramirez, Maria Isabel
Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
title Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
title_full Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
title_fullStr Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
title_full_unstemmed Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
title_short Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
title_sort maternal and neonatal hair cortisol levels are associated with infant neurodevelopment at six months of age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912650/
https://www.ncbi.nlm.nih.gov/pubmed/31752272
http://dx.doi.org/10.3390/jcm8112015
work_keys_str_mv AT caparrosgonzalezrafaela maternalandneonatalhaircortisollevelsareassociatedwithinfantneurodevelopmentatsixmonthsofage
AT romerogonzalezborja maternalandneonatalhaircortisollevelsareassociatedwithinfantneurodevelopmentatsixmonthsofage
AT gonzalezperezraquel maternalandneonatalhaircortisollevelsareassociatedwithinfantneurodevelopmentatsixmonthsofage
AT lucenaprietolidia maternalandneonatalhaircortisollevelsareassociatedwithinfantneurodevelopmentatsixmonthsofage
AT perezgarciamiguel maternalandneonatalhaircortisollevelsareassociatedwithinfantneurodevelopmentatsixmonthsofage
AT cruzquintanafrancisco maternalandneonatalhaircortisollevelsareassociatedwithinfantneurodevelopmentatsixmonthsofage
AT peraltaramirezmariaisabel maternalandneonatalhaircortisollevelsareassociatedwithinfantneurodevelopmentatsixmonthsofage