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Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region
Background: To validate the European Thyroid Imaging and Reporting Data System EU-TIRADS classification in a multi-institutional database of thyroid nodules by analyzing the obtained scores and histopathology results. Methods: A total of 842 thyroid lesions (613 benign, 229 malignant) were identifie...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912671/ https://www.ncbi.nlm.nih.gov/pubmed/31731455 http://dx.doi.org/10.3390/jcm8111781 |
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author | Dobruch-Sobczak, Katarzyna Adamczewski, Zbigniew Szczepanek-Parulska, Ewelina Migda, Bartosz Woliński, Kosma Krauze, Agnieszka Prostko, Piotr Ruchała, Marek Lewiński, Andrzej Jakubowski, Wiesław Dedecjus, Marek |
author_facet | Dobruch-Sobczak, Katarzyna Adamczewski, Zbigniew Szczepanek-Parulska, Ewelina Migda, Bartosz Woliński, Kosma Krauze, Agnieszka Prostko, Piotr Ruchała, Marek Lewiński, Andrzej Jakubowski, Wiesław Dedecjus, Marek |
author_sort | Dobruch-Sobczak, Katarzyna |
collection | PubMed |
description | Background: To validate the European Thyroid Imaging and Reporting Data System EU-TIRADS classification in a multi-institutional database of thyroid nodules by analyzing the obtained scores and histopathology results. Methods: A total of 842 thyroid lesions (613 benign, 229 malignant) were identified in 428 patients (mean age 62.7 years) and scored according to EU-TIRADS, using ultrasound examination. In all tumors, histopathological verification was performed. Results: In EU-TIRADS 2 (154 nodules) all nodules were benign; in EU-TIRADS 3, only 3/93 malignancies were identified. In EU-TIRADS 4, 12/103 were malignant, and in EU-TIRADS 5 (278 benign vs. 214 malignant). The malignant nodules that would not have qualified for biopsy were: EU-TIRADS 3, 2/3 (67%) malignancies were <20 mm, in EU-TIRADS 4, 7/12 (58%) were <15 mm. In EU-TIRADS 5, 72/214 (34%) were <10 mm; in total, 81/229 (36%) malignant lesions would have been missed. The cutoff between EU-TIRADS 3/4 had sensitivity of 100%, specificity of 25.1%. Using cutoff for EU-TIRADS 5, 93.4%, 54.6%, respectively. Conclusion: The application of EU-TIRADS guidelines allowed us to achieve moderate specificity. The vast majority of malignancies in EU-TIRADS 3, 4, and 5 would not have been recommended for biopsy because having a smaller size than that proposed classification. |
format | Online Article Text |
id | pubmed-6912671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69126712020-01-02 Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region Dobruch-Sobczak, Katarzyna Adamczewski, Zbigniew Szczepanek-Parulska, Ewelina Migda, Bartosz Woliński, Kosma Krauze, Agnieszka Prostko, Piotr Ruchała, Marek Lewiński, Andrzej Jakubowski, Wiesław Dedecjus, Marek J Clin Med Article Background: To validate the European Thyroid Imaging and Reporting Data System EU-TIRADS classification in a multi-institutional database of thyroid nodules by analyzing the obtained scores and histopathology results. Methods: A total of 842 thyroid lesions (613 benign, 229 malignant) were identified in 428 patients (mean age 62.7 years) and scored according to EU-TIRADS, using ultrasound examination. In all tumors, histopathological verification was performed. Results: In EU-TIRADS 2 (154 nodules) all nodules were benign; in EU-TIRADS 3, only 3/93 malignancies were identified. In EU-TIRADS 4, 12/103 were malignant, and in EU-TIRADS 5 (278 benign vs. 214 malignant). The malignant nodules that would not have qualified for biopsy were: EU-TIRADS 3, 2/3 (67%) malignancies were <20 mm, in EU-TIRADS 4, 7/12 (58%) were <15 mm. In EU-TIRADS 5, 72/214 (34%) were <10 mm; in total, 81/229 (36%) malignant lesions would have been missed. The cutoff between EU-TIRADS 3/4 had sensitivity of 100%, specificity of 25.1%. Using cutoff for EU-TIRADS 5, 93.4%, 54.6%, respectively. Conclusion: The application of EU-TIRADS guidelines allowed us to achieve moderate specificity. The vast majority of malignancies in EU-TIRADS 3, 4, and 5 would not have been recommended for biopsy because having a smaller size than that proposed classification. MDPI 2019-10-25 /pmc/articles/PMC6912671/ /pubmed/31731455 http://dx.doi.org/10.3390/jcm8111781 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dobruch-Sobczak, Katarzyna Adamczewski, Zbigniew Szczepanek-Parulska, Ewelina Migda, Bartosz Woliński, Kosma Krauze, Agnieszka Prostko, Piotr Ruchała, Marek Lewiński, Andrzej Jakubowski, Wiesław Dedecjus, Marek Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region |
title | Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region |
title_full | Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region |
title_fullStr | Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region |
title_full_unstemmed | Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region |
title_short | Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region |
title_sort | histopathological verification of the diagnostic performance of the eu-tirads classification of thyroid nodules—results of a multicenter study performed in a previously iodine-deficient region |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912671/ https://www.ncbi.nlm.nih.gov/pubmed/31731455 http://dx.doi.org/10.3390/jcm8111781 |
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