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Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region

Background: To validate the European Thyroid Imaging and Reporting Data System EU-TIRADS classification in a multi-institutional database of thyroid nodules by analyzing the obtained scores and histopathology results. Methods: A total of 842 thyroid lesions (613 benign, 229 malignant) were identifie...

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Autores principales: Dobruch-Sobczak, Katarzyna, Adamczewski, Zbigniew, Szczepanek-Parulska, Ewelina, Migda, Bartosz, Woliński, Kosma, Krauze, Agnieszka, Prostko, Piotr, Ruchała, Marek, Lewiński, Andrzej, Jakubowski, Wiesław, Dedecjus, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912671/
https://www.ncbi.nlm.nih.gov/pubmed/31731455
http://dx.doi.org/10.3390/jcm8111781
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author Dobruch-Sobczak, Katarzyna
Adamczewski, Zbigniew
Szczepanek-Parulska, Ewelina
Migda, Bartosz
Woliński, Kosma
Krauze, Agnieszka
Prostko, Piotr
Ruchała, Marek
Lewiński, Andrzej
Jakubowski, Wiesław
Dedecjus, Marek
author_facet Dobruch-Sobczak, Katarzyna
Adamczewski, Zbigniew
Szczepanek-Parulska, Ewelina
Migda, Bartosz
Woliński, Kosma
Krauze, Agnieszka
Prostko, Piotr
Ruchała, Marek
Lewiński, Andrzej
Jakubowski, Wiesław
Dedecjus, Marek
author_sort Dobruch-Sobczak, Katarzyna
collection PubMed
description Background: To validate the European Thyroid Imaging and Reporting Data System EU-TIRADS classification in a multi-institutional database of thyroid nodules by analyzing the obtained scores and histopathology results. Methods: A total of 842 thyroid lesions (613 benign, 229 malignant) were identified in 428 patients (mean age 62.7 years) and scored according to EU-TIRADS, using ultrasound examination. In all tumors, histopathological verification was performed. Results: In EU-TIRADS 2 (154 nodules) all nodules were benign; in EU-TIRADS 3, only 3/93 malignancies were identified. In EU-TIRADS 4, 12/103 were malignant, and in EU-TIRADS 5 (278 benign vs. 214 malignant). The malignant nodules that would not have qualified for biopsy were: EU-TIRADS 3, 2/3 (67%) malignancies were <20 mm, in EU-TIRADS 4, 7/12 (58%) were <15 mm. In EU-TIRADS 5, 72/214 (34%) were <10 mm; in total, 81/229 (36%) malignant lesions would have been missed. The cutoff between EU-TIRADS 3/4 had sensitivity of 100%, specificity of 25.1%. Using cutoff for EU-TIRADS 5, 93.4%, 54.6%, respectively. Conclusion: The application of EU-TIRADS guidelines allowed us to achieve moderate specificity. The vast majority of malignancies in EU-TIRADS 3, 4, and 5 would not have been recommended for biopsy because having a smaller size than that proposed classification.
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spelling pubmed-69126712020-01-02 Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region Dobruch-Sobczak, Katarzyna Adamczewski, Zbigniew Szczepanek-Parulska, Ewelina Migda, Bartosz Woliński, Kosma Krauze, Agnieszka Prostko, Piotr Ruchała, Marek Lewiński, Andrzej Jakubowski, Wiesław Dedecjus, Marek J Clin Med Article Background: To validate the European Thyroid Imaging and Reporting Data System EU-TIRADS classification in a multi-institutional database of thyroid nodules by analyzing the obtained scores and histopathology results. Methods: A total of 842 thyroid lesions (613 benign, 229 malignant) were identified in 428 patients (mean age 62.7 years) and scored according to EU-TIRADS, using ultrasound examination. In all tumors, histopathological verification was performed. Results: In EU-TIRADS 2 (154 nodules) all nodules were benign; in EU-TIRADS 3, only 3/93 malignancies were identified. In EU-TIRADS 4, 12/103 were malignant, and in EU-TIRADS 5 (278 benign vs. 214 malignant). The malignant nodules that would not have qualified for biopsy were: EU-TIRADS 3, 2/3 (67%) malignancies were <20 mm, in EU-TIRADS 4, 7/12 (58%) were <15 mm. In EU-TIRADS 5, 72/214 (34%) were <10 mm; in total, 81/229 (36%) malignant lesions would have been missed. The cutoff between EU-TIRADS 3/4 had sensitivity of 100%, specificity of 25.1%. Using cutoff for EU-TIRADS 5, 93.4%, 54.6%, respectively. Conclusion: The application of EU-TIRADS guidelines allowed us to achieve moderate specificity. The vast majority of malignancies in EU-TIRADS 3, 4, and 5 would not have been recommended for biopsy because having a smaller size than that proposed classification. MDPI 2019-10-25 /pmc/articles/PMC6912671/ /pubmed/31731455 http://dx.doi.org/10.3390/jcm8111781 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dobruch-Sobczak, Katarzyna
Adamczewski, Zbigniew
Szczepanek-Parulska, Ewelina
Migda, Bartosz
Woliński, Kosma
Krauze, Agnieszka
Prostko, Piotr
Ruchała, Marek
Lewiński, Andrzej
Jakubowski, Wiesław
Dedecjus, Marek
Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region
title Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region
title_full Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region
title_fullStr Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region
title_full_unstemmed Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region
title_short Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region
title_sort histopathological verification of the diagnostic performance of the eu-tirads classification of thyroid nodules—results of a multicenter study performed in a previously iodine-deficient region
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912671/
https://www.ncbi.nlm.nih.gov/pubmed/31731455
http://dx.doi.org/10.3390/jcm8111781
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