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Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute to this cell death are inflammation, oxidative stress, and misfolded alpha-s...

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Autores principales: Edwards, George, Gamez, Nazaret, Armijo, Enrique, Kramm, Carlos, Morales, Rodrigo, Taylor-Presse, Kathleen, Schulz, Paul E., Soto, Claudio, Moreno-Gonzalez, Ines
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912680/
https://www.ncbi.nlm.nih.gov/pubmed/31671704
http://dx.doi.org/10.3390/cells8111359
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author Edwards, George
Gamez, Nazaret
Armijo, Enrique
Kramm, Carlos
Morales, Rodrigo
Taylor-Presse, Kathleen
Schulz, Paul E.
Soto, Claudio
Moreno-Gonzalez, Ines
author_facet Edwards, George
Gamez, Nazaret
Armijo, Enrique
Kramm, Carlos
Morales, Rodrigo
Taylor-Presse, Kathleen
Schulz, Paul E.
Soto, Claudio
Moreno-Gonzalez, Ines
author_sort Edwards, George
collection PubMed
description Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute to this cell death are inflammation, oxidative stress, and misfolded alpha-synuclein-induced toxicity. Current treatments are effective at managing the early motor symptoms of the disease, but they become ineffective over time and lead to adverse effects. Previous research using intracerebral stem cell therapy for treatment of PD has provided promising results; however, this method is very invasive and is often associated with unacceptable side effects. In this study, we used an MPTP-injected mouse model of PD and intravenously administered neural precursors (NPs) obtained from mouse embryonic and mesenchymal stem cells. Clinical signs and neuropathology were assessed. Female mice treated with NPs had improved motor function and reduction in the neuroinflammatory response. In terms of safety, there were no tumorigenic formations or any detectable adverse effect after treatment. Our results suggest that peripheral administration of stem cell-derived NPs may be a promising and safe therapy for the recovery of impaired motor function and amelioration of brain pathology in PD.
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spelling pubmed-69126802020-01-02 Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology Edwards, George Gamez, Nazaret Armijo, Enrique Kramm, Carlos Morales, Rodrigo Taylor-Presse, Kathleen Schulz, Paul E. Soto, Claudio Moreno-Gonzalez, Ines Cells Article Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute to this cell death are inflammation, oxidative stress, and misfolded alpha-synuclein-induced toxicity. Current treatments are effective at managing the early motor symptoms of the disease, but they become ineffective over time and lead to adverse effects. Previous research using intracerebral stem cell therapy for treatment of PD has provided promising results; however, this method is very invasive and is often associated with unacceptable side effects. In this study, we used an MPTP-injected mouse model of PD and intravenously administered neural precursors (NPs) obtained from mouse embryonic and mesenchymal stem cells. Clinical signs and neuropathology were assessed. Female mice treated with NPs had improved motor function and reduction in the neuroinflammatory response. In terms of safety, there were no tumorigenic formations or any detectable adverse effect after treatment. Our results suggest that peripheral administration of stem cell-derived NPs may be a promising and safe therapy for the recovery of impaired motor function and amelioration of brain pathology in PD. MDPI 2019-10-30 /pmc/articles/PMC6912680/ /pubmed/31671704 http://dx.doi.org/10.3390/cells8111359 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Edwards, George
Gamez, Nazaret
Armijo, Enrique
Kramm, Carlos
Morales, Rodrigo
Taylor-Presse, Kathleen
Schulz, Paul E.
Soto, Claudio
Moreno-Gonzalez, Ines
Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology
title Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology
title_full Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology
title_fullStr Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology
title_full_unstemmed Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology
title_short Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson’s Disease-Associated Pathology
title_sort peripheral delivery of neural precursor cells ameliorates parkinson’s disease-associated pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912680/
https://www.ncbi.nlm.nih.gov/pubmed/31671704
http://dx.doi.org/10.3390/cells8111359
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