Cargando…

2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years

The 2017 American College of Cardiology/American Heart Association (ACC/AHA) high blood pressure (BP) guideline lowered the cut-off for hypertension, but its age-specific association with cardiovascular disease (CVD) remains inconclusive in different populations. We evaluated the association between...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hokyou, Cho, So Mi Jemma, Park, Jong Heon, Park, Sungha, Kim, Hyeon Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912685/
https://www.ncbi.nlm.nih.gov/pubmed/31683957
http://dx.doi.org/10.3390/jcm8111832
_version_ 1783479515343749120
author Lee, Hokyou
Cho, So Mi Jemma
Park, Jong Heon
Park, Sungha
Kim, Hyeon Chang
author_facet Lee, Hokyou
Cho, So Mi Jemma
Park, Jong Heon
Park, Sungha
Kim, Hyeon Chang
author_sort Lee, Hokyou
collection PubMed
description The 2017 American College of Cardiology/American Heart Association (ACC/AHA) high blood pressure (BP) guideline lowered the cut-off for hypertension, but its age-specific association with cardiovascular disease (CVD) remains inconclusive in different populations. We evaluated the association between high BP according to the 2017 ACC/AHA guideline and CVD risks in Koreans aged 20–94 years. In a nationwide health screening cohort, we included 15,508,537 persons aged 20–94 years without prior CVD. BP was categorized into normal, elevated, stage 1 hypertension, or stage 2 hypertension. The primary outcome was a composite CVD hospitalization (myocardial infarction, stroke, and/or heart failure). Over 10 years of follow-up, CVD incidence rates per 100,000 person-years were 105.4, 168.3, 215.9, and 641.2 for normal, elevated BP, stage 1, and stage 2 hypertension, respectively. The age-specific hazard ratios of stage 1 hypertension compared to normal BP were 1.41 (1.34–1.48) at ages 20–34, 1.54 (1.51–1.57) at ages 35–49, 1.38 (1.35–1.40) at ages 50–64, 1.21 (1.19–1.24) at ages 65–79, and 1.11 (1.03–1.19) at ages 80–94 years. With the lowered BP cut-off, 130/80 mmHg, population attributable fraction for CVD was 32.2%. In conclusion, stage 1 hypertension was significantly associated with a higher CVD risk across entire adulthood. The new definition of hypertension may have a substantial population impact on primary CVD prevention.
format Online
Article
Text
id pubmed-6912685
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69126852020-01-02 2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years Lee, Hokyou Cho, So Mi Jemma Park, Jong Heon Park, Sungha Kim, Hyeon Chang J Clin Med Article The 2017 American College of Cardiology/American Heart Association (ACC/AHA) high blood pressure (BP) guideline lowered the cut-off for hypertension, but its age-specific association with cardiovascular disease (CVD) remains inconclusive in different populations. We evaluated the association between high BP according to the 2017 ACC/AHA guideline and CVD risks in Koreans aged 20–94 years. In a nationwide health screening cohort, we included 15,508,537 persons aged 20–94 years without prior CVD. BP was categorized into normal, elevated, stage 1 hypertension, or stage 2 hypertension. The primary outcome was a composite CVD hospitalization (myocardial infarction, stroke, and/or heart failure). Over 10 years of follow-up, CVD incidence rates per 100,000 person-years were 105.4, 168.3, 215.9, and 641.2 for normal, elevated BP, stage 1, and stage 2 hypertension, respectively. The age-specific hazard ratios of stage 1 hypertension compared to normal BP were 1.41 (1.34–1.48) at ages 20–34, 1.54 (1.51–1.57) at ages 35–49, 1.38 (1.35–1.40) at ages 50–64, 1.21 (1.19–1.24) at ages 65–79, and 1.11 (1.03–1.19) at ages 80–94 years. With the lowered BP cut-off, 130/80 mmHg, population attributable fraction for CVD was 32.2%. In conclusion, stage 1 hypertension was significantly associated with a higher CVD risk across entire adulthood. The new definition of hypertension may have a substantial population impact on primary CVD prevention. MDPI 2019-11-01 /pmc/articles/PMC6912685/ /pubmed/31683957 http://dx.doi.org/10.3390/jcm8111832 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Hokyou
Cho, So Mi Jemma
Park, Jong Heon
Park, Sungha
Kim, Hyeon Chang
2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years
title 2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years
title_full 2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years
title_fullStr 2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years
title_full_unstemmed 2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years
title_short 2017 ACC/AHA Blood Pressure Classification and Cardiovascular Disease in 15 Million Adults of Age 20–94 Years
title_sort 2017 acc/aha blood pressure classification and cardiovascular disease in 15 million adults of age 20–94 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912685/
https://www.ncbi.nlm.nih.gov/pubmed/31683957
http://dx.doi.org/10.3390/jcm8111832
work_keys_str_mv AT leehokyou 2017accahabloodpressureclassificationandcardiovasculardiseasein15millionadultsofage2094years
AT chosomijemma 2017accahabloodpressureclassificationandcardiovasculardiseasein15millionadultsofage2094years
AT parkjongheon 2017accahabloodpressureclassificationandcardiovasculardiseasein15millionadultsofage2094years
AT parksungha 2017accahabloodpressureclassificationandcardiovasculardiseasein15millionadultsofage2094years
AT kimhyeonchang 2017accahabloodpressureclassificationandcardiovasculardiseasein15millionadultsofage2094years