Mucins and Asthma: Are We Headed to the Revolutionary Road?

Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal...

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Autores principales: Santus, Pierachille, Radovanovic, Dejan, Chiumello, Davide Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912707/
https://www.ncbi.nlm.nih.gov/pubmed/31766166
http://dx.doi.org/10.3390/jcm8111955
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author Santus, Pierachille
Radovanovic, Dejan
Chiumello, Davide Alberto
author_facet Santus, Pierachille
Radovanovic, Dejan
Chiumello, Davide Alberto
author_sort Santus, Pierachille
collection PubMed
description Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma.
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spelling pubmed-69127072020-01-02 Mucins and Asthma: Are We Headed to the Revolutionary Road? Santus, Pierachille Radovanovic, Dejan Chiumello, Davide Alberto J Clin Med Editorial Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma. MDPI 2019-11-13 /pmc/articles/PMC6912707/ /pubmed/31766166 http://dx.doi.org/10.3390/jcm8111955 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Santus, Pierachille
Radovanovic, Dejan
Chiumello, Davide Alberto
Mucins and Asthma: Are We Headed to the Revolutionary Road?
title Mucins and Asthma: Are We Headed to the Revolutionary Road?
title_full Mucins and Asthma: Are We Headed to the Revolutionary Road?
title_fullStr Mucins and Asthma: Are We Headed to the Revolutionary Road?
title_full_unstemmed Mucins and Asthma: Are We Headed to the Revolutionary Road?
title_short Mucins and Asthma: Are We Headed to the Revolutionary Road?
title_sort mucins and asthma: are we headed to the revolutionary road?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912707/
https://www.ncbi.nlm.nih.gov/pubmed/31766166
http://dx.doi.org/10.3390/jcm8111955
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