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Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma

Background: The prognostic role of the translational factor, elongation factor-1 alpha 1 (EEF1A1), in colon cancer is unclear. Objectives: The present study aimed to investigate the expression of EEF1A in tissues obtained from patients with stage II and III colon cancer and analyze its association w...

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Autores principales: Joung, Eun kyo, Kim, Jiyoung, Yoon, Nara, Maeng, Lee-so, Kim, Ji Hoon, Park, Sungsoo, Kang, Keunsoo, Kim, Jeong Seon, Ahn, Young-Ho, Ko, Yoon Ho, Byun, Jae Ho, Hong, Ji Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912729/
https://www.ncbi.nlm.nih.gov/pubmed/31703307
http://dx.doi.org/10.3390/jcm8111903
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author Joung, Eun kyo
Kim, Jiyoung
Yoon, Nara
Maeng, Lee-so
Kim, Ji Hoon
Park, Sungsoo
Kang, Keunsoo
Kim, Jeong Seon
Ahn, Young-Ho
Ko, Yoon Ho
Byun, Jae Ho
Hong, Ji Hyung
author_facet Joung, Eun kyo
Kim, Jiyoung
Yoon, Nara
Maeng, Lee-so
Kim, Ji Hoon
Park, Sungsoo
Kang, Keunsoo
Kim, Jeong Seon
Ahn, Young-Ho
Ko, Yoon Ho
Byun, Jae Ho
Hong, Ji Hyung
author_sort Joung, Eun kyo
collection PubMed
description Background: The prognostic role of the translational factor, elongation factor-1 alpha 1 (EEF1A1), in colon cancer is unclear. Objectives: The present study aimed to investigate the expression of EEF1A in tissues obtained from patients with stage II and III colon cancer and analyze its association with patient prognosis. Methods: A total of 281 patients with colon cancer who underwent curative resection were analyzed according to EEF1A1 expression. Results: The five-year overall survival in the high-EEF1A1 group was 87.7%, whereas it was 65.6% in the low-EEF1A1 expression group (hazard ratio (HR) 2.47, 95% confidence interval (CI) 1.38–4.44, p = 0.002). The five-year disease-free survival of patients with high EEF1A1 expression was 82.5%, which was longer than the rate of 55.4% observed for patients with low EEF1A1 expression (HR 2.94, 95% CI 1.72–5.04, p < 0.001). Univariate Cox regression analysis indicated that age, preoperative carcinoembryonic antigen level, adjuvant treatment, total number of metastatic lymph nodes, and EEF1A1 expression level were significant prognostic factors for death. In multivariate analysis, expression of EEF1A1 was an independent prognostic factor associated with death (HR 3.01, 95% CI 1.636–5.543, p < 0.001). EEF1A1 expression was also an independent prognostic factor for disease-free survival in multivariate analysis (HR 2.54, 95% CI 1.459–4.434, p < 0.001). Conclusions: Our study demonstrated that high expression of EEF1A1 has a favorable prognostic effect on patients with colon adenocarcinoma.
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spelling pubmed-69127292020-01-02 Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma Joung, Eun kyo Kim, Jiyoung Yoon, Nara Maeng, Lee-so Kim, Ji Hoon Park, Sungsoo Kang, Keunsoo Kim, Jeong Seon Ahn, Young-Ho Ko, Yoon Ho Byun, Jae Ho Hong, Ji Hyung J Clin Med Article Background: The prognostic role of the translational factor, elongation factor-1 alpha 1 (EEF1A1), in colon cancer is unclear. Objectives: The present study aimed to investigate the expression of EEF1A in tissues obtained from patients with stage II and III colon cancer and analyze its association with patient prognosis. Methods: A total of 281 patients with colon cancer who underwent curative resection were analyzed according to EEF1A1 expression. Results: The five-year overall survival in the high-EEF1A1 group was 87.7%, whereas it was 65.6% in the low-EEF1A1 expression group (hazard ratio (HR) 2.47, 95% confidence interval (CI) 1.38–4.44, p = 0.002). The five-year disease-free survival of patients with high EEF1A1 expression was 82.5%, which was longer than the rate of 55.4% observed for patients with low EEF1A1 expression (HR 2.94, 95% CI 1.72–5.04, p < 0.001). Univariate Cox regression analysis indicated that age, preoperative carcinoembryonic antigen level, adjuvant treatment, total number of metastatic lymph nodes, and EEF1A1 expression level were significant prognostic factors for death. In multivariate analysis, expression of EEF1A1 was an independent prognostic factor associated with death (HR 3.01, 95% CI 1.636–5.543, p < 0.001). EEF1A1 expression was also an independent prognostic factor for disease-free survival in multivariate analysis (HR 2.54, 95% CI 1.459–4.434, p < 0.001). Conclusions: Our study demonstrated that high expression of EEF1A1 has a favorable prognostic effect on patients with colon adenocarcinoma. MDPI 2019-11-07 /pmc/articles/PMC6912729/ /pubmed/31703307 http://dx.doi.org/10.3390/jcm8111903 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Joung, Eun kyo
Kim, Jiyoung
Yoon, Nara
Maeng, Lee-so
Kim, Ji Hoon
Park, Sungsoo
Kang, Keunsoo
Kim, Jeong Seon
Ahn, Young-Ho
Ko, Yoon Ho
Byun, Jae Ho
Hong, Ji Hyung
Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma
title Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma
title_full Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma
title_fullStr Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma
title_full_unstemmed Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma
title_short Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma
title_sort expression of eef1a1 is associated with prognosis of patients with colon adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912729/
https://www.ncbi.nlm.nih.gov/pubmed/31703307
http://dx.doi.org/10.3390/jcm8111903
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