Cargando…

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations

The three subtypes (α, β, and γ) of the retinoic acid receptor (RAR) are ligand-dependent transcription factors that mediate retinoic acid signaling by forming heterodimers with the retinoid X receptor (RXR). Heterodimers are functional units that bind ligands (retinoids), transcriptional co-regulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	le Maire, Albane, Teyssier, Catherine, Balaguer, Patrick, Bourguet, William, Germain, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912802/ https://www.ncbi.nlm.nih.gov/pubmed/31694317 http://dx.doi.org/10.3390/cells8111392

Ejemplares similares

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury
por: van Neerven, Sabien, et al.
Publicado: (2007)

RAR-Dependent and RAR-Independent RXR Signaling in Stem-like Glioma Cells
por: Dabrock, Amanda, et al.
Publicado: (2023)

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
por: Chandra, Vikas, et al.
Publicado: (2017)

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR–RXR
por: Osz, Judit, et al.
Publicado: (2020)

RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner
por: Xu, Lin, et al.
Publicado: (2017)

Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
por: Delfosse, Vanessa, et al.
Publicado: (2021)

Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity
por: Nomoto, Masanori, et al.
Publicado: (2012)

Amplified Inhibition of Stellate Cell Activation Pathways by PPAR-γ, RAR and RXR Agonists
por: Sharvit, Efrat, et al.
Publicado: (2013)

Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin
por: Gericke, Janine, et al.
Publicado: (2013)

The ETS Family Member TEL Binds to Nuclear Receptors RAR and RXR and Represses Gene Activation
por: Meester-Smoor, Magda A., et al.
Publicado: (2011)

RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements
por: Chatagnon, Amandine, et al.
Publicado: (2015)

Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding
por: Rehó, Bálint, et al.
Publicado: (2023)

Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist
por: Koshiishi, Chie, et al.
Publicado: (2019)

Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer
por: Belorusova, Anna Y, et al.
Publicado: (2020)

Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides
por: Dauwe, Yannick, et al.
Publicado: (2023)

Energy status regulates levels of the RAR/RXR ligand 9-cis-retinoic acid in mammalian tissues: Glucose reduces its synthesis in β-cells
por: Yoo, Hong Sik, et al.
Publicado: (2023)

PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia
por: Li, Ke, et al.
Publicado: (2020)

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
por: Kojetin, Douglas J., et al.
Publicado: (2015)

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization
por: Scheepstra, Marcel, et al.
Publicado: (2017)

RXR Ligands Negatively Regulate Thrombosis and Hemostasis
por: Unsworth, Amanda J., et al.
Publicado: (2017)

SAT006 Activation Of The CAR/RXR Heterodimer By Pesticides And Induced Metabolic Effects
por: Dauwe, Yannick, et al.
Publicado: (2023)

In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator
por: D’Aniello, Enrico, et al.
Publicado: (2019)

Loss of RAR-α and RXR-α and enhanced caspase-3-dependent apoptosis in N-acetyl-p-aminophenol-induced liver injury in mice is tissue factor dependent
por: Abdel-Bakky, Mohamed Sadek, et al.
Publicado: (2021)

Retinoic Acid and GM-CSF Coordinately Induce Retinal Dehydrogenase 2 (RALDH2) Expression through Cooperation between the RAR/RXR Complex and Sp1 in Dendritic Cells
por: Ohoka, Yoshiharu, et al.
Publicado: (2014)

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist
por: Nadendla, Eswarkumar, et al.
Publicado: (2015)

Is RARS-T a new disease entity or a subtype of RARS or ET?
por: Bang, Soo-Mee
Publicado: (2010)

Analysis of RXR/THR and RXR/PPARG2 Heterodimerization by Bioluminescence Resonance Energy Transfer (BRET)
por: Mulero, Miquel, et al.
Publicado: (2013)

Epigenetic regulation by RARα maintains ligand-independent transcriptional activity
por: Laursen, Kristian B., et al.
Publicado: (2012)

Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer
por: Zhao, Mohan, et al.
Publicado: (2022)

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages
por: Daniel, Bence, et al.
Publicado: (2018)

Molecular basis of ligand-dependent Nurr1-RXRα activation
por: Yu, Xiaoyu, et al.
Publicado: (2023)

Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis
por: Bosch, Almudena, et al.
Publicado: (2012)

RXRα Regulates the Development of Resident Tissue Macrophages
por: Philpott, Jordan, et al.
Publicado: (2022)

Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs
por: Koshy, Aysis, et al.
Publicado: (2022)

Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha
por: Conde, Isabel, et al.
Publicado: (2008)

Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
por: Rochette-Egly, Cécile, et al.
Publicado: (2009)

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages
por: Daniel, Bence, et al.
Publicado: (2014)

Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review
por: Borthwick, Alan D., et al.
Publicado: (2020)

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ
por: Kilu, Whitney, et al.
Publicado: (2021)

Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity
por: Sarti, Federica, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9f6q593nmmqep9a3jb6s5galso