deSALT: fast and accurate long transcriptomic read alignment with de Bruijn graph-based index

The alignment of long-read RNA sequencing reads is non-trivial due to high sequencing errors and complicated gene structures. We propose deSALT, a tailored two-pass alignment approach, which constructs graph-based alignment skeletons to infer exons and uses them to generate spliced reference sequenc...

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Detalles Bibliográficos
Autores principales: Liu, Bo, Liu, Yadong, Li, Junyi, Guo, Hongzhe, Zang, Tianyi, Wang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913027/
https://www.ncbi.nlm.nih.gov/pubmed/31842925
http://dx.doi.org/10.1186/s13059-019-1895-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913027/
https://www.ncbi.nlm.nih.gov/pubmed/31842925
http://dx.doi.org/10.1186/s13059-019-1895-9

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