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deSALT: fast and accurate long transcriptomic read alignment with de Bruijn graph-based index
The alignment of long-read RNA sequencing reads is non-trivial due to high sequencing errors and complicated gene structures. We propose deSALT, a tailored two-pass alignment approach, which constructs graph-based alignment skeletons to infer exons and uses them to generate spliced reference sequenc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913027/ https://www.ncbi.nlm.nih.gov/pubmed/31842925 http://dx.doi.org/10.1186/s13059-019-1895-9 |