Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

In response to foreign RNA, cellular antiviral mechanisms stimulate high expression of interferon-induced proteins with tetratricopeptide repeats (IFITs). Two members of the IFIT protein family, IFIT1 and IFIT5, are capable of binding the very terminal 5′ end of mRNA. In eukaryotes, these mRNA termi...

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Detalles Bibliográficos
Autores principales: Miedziak, Beata, Dobieżyńska, Anna, Darżynkiewicz, Zbigniew M., Bartkowska, Julia, Miszkiewicz, Joanna, Kowalska, Joanna, Warminski, Marcin, Tyras, Michal, Trylska, Joanna, Jemielity, Jacek, Darzynkiewicz, Edward, Grzela, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913129/
https://www.ncbi.nlm.nih.gov/pubmed/31658992
http://dx.doi.org/10.1261/rna.073304.119

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