Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma

The tumor genome of a patient with advanced pancreatic cancer was sequenced to identify potential therapeutic targetable mutations after standard of care failed to produce any significant overall response. Matched tumor-normal whole-genome sequencing revealed somatic mutations in BRAF, TP53, CDKN2A,...

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Detalles Bibliográficos
Autores principales: Wrzeszczynski, Kazimierz O., Rahman, Sadia, Frank, Mayu O., Arora, Kanika, Shah, Minita, Geiger, Heather, Felice, Vanessa, Manaa, Dina, Dikoglu, Esra, Khaira, Depinder, Chimpiri, A. Rao, Michelini, Vanessa V., Jobanputra, Vaidehi, Darnell, Robert B., Powers, Scott, Choi, Minsig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Rapid Cancer Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913137/
https://www.ncbi.nlm.nih.gov/pubmed/31519698
http://dx.doi.org/10.1101/mcs.a004424

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