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Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma

Clonal heterogeneity and evolution of mantle cell lymphoma (MCL) remain unclear despite the progress in our understanding of its biology. Here, we report a 71-yr-old male patient with an aggressive MCL and depict the clonal evolution from initial diagnosis of typical MCL to relapsed blastoid MCL. Du...

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Autores principales: Tashkandi, Hammad, Petrova-Drus, Kseniya, Batlevi, Connie Lee, Arcila, Maria E., Roshal, Mikhail, Sen, Filiz, Yao, Jinjuan, Baik, Jeeyeon, Bilger, Ashley, Singh, Jessica, de Frank, Stephanie, Kumar, Anita, Aryeequaye, Ruth, Zhang, Yanming, Dogan, Ahmet, Xiao, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913152/
https://www.ncbi.nlm.nih.gov/pubmed/31395597
http://dx.doi.org/10.1101/mcs.a004259
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author Tashkandi, Hammad
Petrova-Drus, Kseniya
Batlevi, Connie Lee
Arcila, Maria E.
Roshal, Mikhail
Sen, Filiz
Yao, Jinjuan
Baik, Jeeyeon
Bilger, Ashley
Singh, Jessica
de Frank, Stephanie
Kumar, Anita
Aryeequaye, Ruth
Zhang, Yanming
Dogan, Ahmet
Xiao, Wenbin
author_facet Tashkandi, Hammad
Petrova-Drus, Kseniya
Batlevi, Connie Lee
Arcila, Maria E.
Roshal, Mikhail
Sen, Filiz
Yao, Jinjuan
Baik, Jeeyeon
Bilger, Ashley
Singh, Jessica
de Frank, Stephanie
Kumar, Anita
Aryeequaye, Ruth
Zhang, Yanming
Dogan, Ahmet
Xiao, Wenbin
author_sort Tashkandi, Hammad
collection PubMed
description Clonal heterogeneity and evolution of mantle cell lymphoma (MCL) remain unclear despite the progress in our understanding of its biology. Here, we report a 71-yr-old male patient with an aggressive MCL and depict the clonal evolution from initial diagnosis of typical MCL to relapsed blastoid MCL. During the course of the disease, the patient was diagnosed with classic Hodgkin lymphoma (CHL) and received a CHL therapeutic regimen. Molecular analysis by next-generation sequencing of both MCL and CHL demonstrated clonally related CHL with characteristic immunophenotype and PDL1/2 gains. Moreover, our data illustrate the clonal heterogeneity and acquisition of additional genetic aberrations including a rare fusion of SEC22B-NOTCH2 in the process of clonal evolution. Evidence obtained from our comprehensive immunophenotypic and genetic studies indicates that MCL and CHL can originate from a common precursor by divergent clonal evolution, which may pose a therapeutic challenge.
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spelling pubmed-69131522019-12-26 Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma Tashkandi, Hammad Petrova-Drus, Kseniya Batlevi, Connie Lee Arcila, Maria E. Roshal, Mikhail Sen, Filiz Yao, Jinjuan Baik, Jeeyeon Bilger, Ashley Singh, Jessica de Frank, Stephanie Kumar, Anita Aryeequaye, Ruth Zhang, Yanming Dogan, Ahmet Xiao, Wenbin Cold Spring Harb Mol Case Stud Research Report Clonal heterogeneity and evolution of mantle cell lymphoma (MCL) remain unclear despite the progress in our understanding of its biology. Here, we report a 71-yr-old male patient with an aggressive MCL and depict the clonal evolution from initial diagnosis of typical MCL to relapsed blastoid MCL. During the course of the disease, the patient was diagnosed with classic Hodgkin lymphoma (CHL) and received a CHL therapeutic regimen. Molecular analysis by next-generation sequencing of both MCL and CHL demonstrated clonally related CHL with characteristic immunophenotype and PDL1/2 gains. Moreover, our data illustrate the clonal heterogeneity and acquisition of additional genetic aberrations including a rare fusion of SEC22B-NOTCH2 in the process of clonal evolution. Evidence obtained from our comprehensive immunophenotypic and genetic studies indicates that MCL and CHL can originate from a common precursor by divergent clonal evolution, which may pose a therapeutic challenge. Cold Spring Harbor Laboratory Press 2019-12 /pmc/articles/PMC6913152/ /pubmed/31395597 http://dx.doi.org/10.1101/mcs.a004259 Text en © 2019 Tashkandi et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.
spellingShingle Research Report
Tashkandi, Hammad
Petrova-Drus, Kseniya
Batlevi, Connie Lee
Arcila, Maria E.
Roshal, Mikhail
Sen, Filiz
Yao, Jinjuan
Baik, Jeeyeon
Bilger, Ashley
Singh, Jessica
de Frank, Stephanie
Kumar, Anita
Aryeequaye, Ruth
Zhang, Yanming
Dogan, Ahmet
Xiao, Wenbin
Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma
title Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma
title_full Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma
title_fullStr Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma
title_full_unstemmed Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma
title_short Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma
title_sort divergent clonal evolution of a common precursor to mantle cell lymphoma and classic hodgkin lymphoma
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913152/
https://www.ncbi.nlm.nih.gov/pubmed/31395597
http://dx.doi.org/10.1101/mcs.a004259
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