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Recent advances in understanding and managing pediatric inflammatory bowel disease

The landscape of pediatric inflammatory bowel disease is rapidly evolving. The therapeutic advances seen in the adult arena are rapidly being adopted by pediatric gastroenterologists and evaluated in both controlled trials and real-world experience. Though anti-tumor necrosis factor agents have been...

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Detalles Bibliográficos
Autores principales: Gurram, Bhaskar, Patel, Ashish S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913196/
https://www.ncbi.nlm.nih.gov/pubmed/31885858
http://dx.doi.org/10.12688/f1000research.19609.1
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author Gurram, Bhaskar
Patel, Ashish S.
author_facet Gurram, Bhaskar
Patel, Ashish S.
author_sort Gurram, Bhaskar
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description The landscape of pediatric inflammatory bowel disease is rapidly evolving. The therapeutic advances seen in the adult arena are rapidly being adopted by pediatric gastroenterologists and evaluated in both controlled trials and real-world experience. Though anti-tumor necrosis factor agents have been the primary therapy over the last decade, recently there has been an expansion of therapeutic targets and alternative mechanism of action drugs with a focus on individualized and personalized therapy. By reviewing epidemiology, pathophysiology, and goals of treatment, we hope to frame the discussion of current and novel therapeutics for the pediatric gastroenterologist. As scientific discovery continues to push the envelope in defining our understanding of pediatric inflammatory bowel disease, the current era of therapeutics gives us hope that a cure may be realized soon.
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spelling pubmed-69131962019-12-27 Recent advances in understanding and managing pediatric inflammatory bowel disease Gurram, Bhaskar Patel, Ashish S. F1000Res Review The landscape of pediatric inflammatory bowel disease is rapidly evolving. The therapeutic advances seen in the adult arena are rapidly being adopted by pediatric gastroenterologists and evaluated in both controlled trials and real-world experience. Though anti-tumor necrosis factor agents have been the primary therapy over the last decade, recently there has been an expansion of therapeutic targets and alternative mechanism of action drugs with a focus on individualized and personalized therapy. By reviewing epidemiology, pathophysiology, and goals of treatment, we hope to frame the discussion of current and novel therapeutics for the pediatric gastroenterologist. As scientific discovery continues to push the envelope in defining our understanding of pediatric inflammatory bowel disease, the current era of therapeutics gives us hope that a cure may be realized soon. F1000 Research Limited 2019-12-13 /pmc/articles/PMC6913196/ /pubmed/31885858 http://dx.doi.org/10.12688/f1000research.19609.1 Text en Copyright: © 2019 Gurram B and Patel AS http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gurram, Bhaskar
Patel, Ashish S.
Recent advances in understanding and managing pediatric inflammatory bowel disease
title Recent advances in understanding and managing pediatric inflammatory bowel disease
title_full Recent advances in understanding and managing pediatric inflammatory bowel disease
title_fullStr Recent advances in understanding and managing pediatric inflammatory bowel disease
title_full_unstemmed Recent advances in understanding and managing pediatric inflammatory bowel disease
title_short Recent advances in understanding and managing pediatric inflammatory bowel disease
title_sort recent advances in understanding and managing pediatric inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913196/
https://www.ncbi.nlm.nih.gov/pubmed/31885858
http://dx.doi.org/10.12688/f1000research.19609.1
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