How common are single gene mutations as a cause for lacunar stroke?: A targeted gene panel study

OBJECTIVES: To determine the frequency of rare and pertinent disease-causing variants in small vessel disease (SVD)-associated genes (such as NOTCH3, HTRA1, COL4A1, COL4A2, FOXC1, TREX1, and GLA) in cerebral SVD, we performed targeted gene sequencing in 950 patients with younger-onset apparently spo...

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Detalles Bibliográficos
Autores principales: Tan, Rhea Y.Y., Traylor, Matthew, Megy, Karyn, Duarte, Daniel, Deevi, Sri V.V., Shamardina, Olga, Mapeta, Rutendo P., Ouwehand, Willem H., Gräf, Stefan, Downes, Kate, Markus, Hugh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913325/
https://www.ncbi.nlm.nih.gov/pubmed/31719132
http://dx.doi.org/10.1212/WNL.0000000000008544

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