Cargando…
The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM)
The microbiota composition of the offspring of women with gestational diabetes mellitus (GDM), a common pregnancy complication, is still little known. We investigated whether the GDM offspring gut microbiota composition is associated with the maternal nutritional habits, metabolic variables or pregn...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913919/ https://www.ncbi.nlm.nih.gov/pubmed/31841548 http://dx.doi.org/10.1371/journal.pone.0226545 |
_version_ | 1783479713869594624 |
---|---|
author | Ponzo, Valentina Ferrocino, Ilario Zarovska, Adriana Amenta, Maria Bernadette Leone, Filomena Monzeglio, Clara Rosato, Rosalba Pellegrini, Marianna Gambino, Roberto Cassader, Maurizio Ghigo, Ezio Cocolin, Luca Bo, Simona |
author_facet | Ponzo, Valentina Ferrocino, Ilario Zarovska, Adriana Amenta, Maria Bernadette Leone, Filomena Monzeglio, Clara Rosato, Rosalba Pellegrini, Marianna Gambino, Roberto Cassader, Maurizio Ghigo, Ezio Cocolin, Luca Bo, Simona |
author_sort | Ponzo, Valentina |
collection | PubMed |
description | The microbiota composition of the offspring of women with gestational diabetes mellitus (GDM), a common pregnancy complication, is still little known. We investigated whether the GDM offspring gut microbiota composition is associated with the maternal nutritional habits, metabolic variables or pregnancy outcomes. Furthermore, we compared the GDM offspring microbiota to the microbiota of normoglycemic-mother offspring. Fecal samples of 29 GDM infants were collected during the first week of life and assessed by 16S amplicon-based sequencing. The offspring’s microbiota showed significantly lower α-diversity than the corresponding mothers. Earlier maternal nutritional habits were more strongly associated with the offspring microbiota (maternal oligosaccharide positively with infant Ruminococcus, maternal saturated fat intake inversely with infant Rikenellaceae and Ruminococcus) than last-trimester maternal habits. Principal coordinate analysis showed a separation of the infant microbiota according to the type of feeding (breastfeeding vs formula-feeding), displaying in breast-fed infants a higher abundance of Bifidobacterium. A few Bacteroides and Blautia oligotypes were shared by the GDM mothers and their offspring, suggesting a maternal microbial imprinting. Finally, GDM infants showed higher relative abundance of pro-inflammatory taxa than infants from healthy women. In conclusion, many maternal conditions impact on the microbiota composition of GDM offspring whose microbiota showed increased abundance of pro-inflammatory taxa. |
format | Online Article Text |
id | pubmed-6913919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69139192019-12-27 The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM) Ponzo, Valentina Ferrocino, Ilario Zarovska, Adriana Amenta, Maria Bernadette Leone, Filomena Monzeglio, Clara Rosato, Rosalba Pellegrini, Marianna Gambino, Roberto Cassader, Maurizio Ghigo, Ezio Cocolin, Luca Bo, Simona PLoS One Research Article The microbiota composition of the offspring of women with gestational diabetes mellitus (GDM), a common pregnancy complication, is still little known. We investigated whether the GDM offspring gut microbiota composition is associated with the maternal nutritional habits, metabolic variables or pregnancy outcomes. Furthermore, we compared the GDM offspring microbiota to the microbiota of normoglycemic-mother offspring. Fecal samples of 29 GDM infants were collected during the first week of life and assessed by 16S amplicon-based sequencing. The offspring’s microbiota showed significantly lower α-diversity than the corresponding mothers. Earlier maternal nutritional habits were more strongly associated with the offspring microbiota (maternal oligosaccharide positively with infant Ruminococcus, maternal saturated fat intake inversely with infant Rikenellaceae and Ruminococcus) than last-trimester maternal habits. Principal coordinate analysis showed a separation of the infant microbiota according to the type of feeding (breastfeeding vs formula-feeding), displaying in breast-fed infants a higher abundance of Bifidobacterium. A few Bacteroides and Blautia oligotypes were shared by the GDM mothers and their offspring, suggesting a maternal microbial imprinting. Finally, GDM infants showed higher relative abundance of pro-inflammatory taxa than infants from healthy women. In conclusion, many maternal conditions impact on the microbiota composition of GDM offspring whose microbiota showed increased abundance of pro-inflammatory taxa. Public Library of Science 2019-12-16 /pmc/articles/PMC6913919/ /pubmed/31841548 http://dx.doi.org/10.1371/journal.pone.0226545 Text en © 2019 Ponzo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ponzo, Valentina Ferrocino, Ilario Zarovska, Adriana Amenta, Maria Bernadette Leone, Filomena Monzeglio, Clara Rosato, Rosalba Pellegrini, Marianna Gambino, Roberto Cassader, Maurizio Ghigo, Ezio Cocolin, Luca Bo, Simona The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM) |
title | The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM) |
title_full | The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM) |
title_fullStr | The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM) |
title_full_unstemmed | The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM) |
title_short | The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM) |
title_sort | microbiota composition of the offspring of patients with gestational diabetes mellitus (gdm) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913919/ https://www.ncbi.nlm.nih.gov/pubmed/31841548 http://dx.doi.org/10.1371/journal.pone.0226545 |
work_keys_str_mv | AT ponzovalentina themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT ferrocinoilario themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT zarovskaadriana themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT amentamariabernadette themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT leonefilomena themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT monzeglioclara themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT rosatorosalba themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT pellegrinimarianna themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT gambinoroberto themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT cassadermaurizio themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT ghigoezio themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT cocolinluca themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT bosimona themicrobiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT ponzovalentina microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT ferrocinoilario microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT zarovskaadriana microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT amentamariabernadette microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT leonefilomena microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT monzeglioclara microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT rosatorosalba microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT pellegrinimarianna microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT gambinoroberto microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT cassadermaurizio microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT ghigoezio microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT cocolinluca microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm AT bosimona microbiotacompositionoftheoffspringofpatientswithgestationaldiabetesmellitusgdm |