Cargando…

Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs

Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood(1-3). A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase (SDH)-deficiency and global DNA hyper-methylation(4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flavahan, William A, Drier, Yotam, Johnstone, Sarah E., Hemming, Matthew L., Tarjan, Daniel R., Hegazi, Esmat, Shareef, Sarah J., Javed, Nauman M., Raut, Chandrajit P., Eschle, Benjamin K., Gokhale, Prafulla C., Hornick, Jason L., Sicinska, Ewa T., Demetri, George D., Bernstein, Bradley E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913936/ https://www.ncbi.nlm.nih.gov/pubmed/31666694 http://dx.doi.org/10.1038/s41586-019-1668-3

Ejemplares similares

Targeted therapy in SDH-deficient GIST
por: Nannini, Margherita, et al.
Publicado: (2021)

SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
por: Schipani, Angela, et al.
Publicado: (2023)

Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)
por: Nannini, Margherita, et al.
Publicado: (2014)

Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways
por: Pantaleo, Maria A, et al.
Publicado: (2015)

Metastatic SDH-Deficient GIST Diagnosed during Pregnancy: Approach to a Complex Case
por: Chennouf, Anas, et al.
Publicado: (2022)

Gain of FGF4 is a frequent event in KIT/PDGFRA/SDH/RAS‐P WT GIST
por: Urbini, Milena, et al.
Publicado: (2019)

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
por: Schaefer, Inga-Marie, et al.
Publicado: (2017)

Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST
por: Astolfi, Annalisa, et al.
Publicado: (2020)

Radio digital SDH/
por: Castellanos Moreno, Fabiola Melina
Publicado: (2001)

Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST
por: Urbini, Milena, et al.
Publicado: (2020)

Epigenome editing strategies for the functional annotation of CTCF insulators
por: Tarjan, Daniel R., et al.
Publicado: (2019)

Insulator dysfunction and oncogene activation in IDH mutant gliomas
por: Flavahan, William A., et al.
Publicado: (2015)

Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents
por: Ricci, Riccardo, et al.
Publicado: (2019)

Two shikimate dehydrogenases, VvSDH3 and VvSDH4, are involved in gallic acid biosynthesis in grapevine
por: Bontpart, Thibaut, et al.
Publicado: (2016)

Do Two Machine-Learning Based Prognostic Signatures for Breast Cancer Capture the Same Biological Processes?
por: Drier, Yotam, et al.
Publicado: (2011)

Effect of gastrointestinal resection on sunitinib exposure in patients with GIST
por: de Wit, Djoeke, et al.
Publicado: (2014)

Next Generation SDH/SONET: Evolution or Revolution?
por: Van Helvoort, Huub
Publicado: (2005)

SARS-CoV-2 infection perturbs enhancer mediated transcriptional regulation of key pathways
por: Yedidya, Yahel, et al.
Publicado: (2023)

A GIST or not a GIST? That is the question
por: Chrysanthos, Nikolaos, et al.
Publicado: (2014)

Recent advances in the genetics of SDH-related paraganglioma and pheochromocytoma
por: Hensen, Erik F., et al.
Publicado: (2010)

Coupling GSN to SONET-OC48/SDH16
por: Van Praag, A, et al.
Publicado: (2001)

Bayesian approach to determining penetrance of pathogenic SDH variants
por: Benn, Diana E, et al.
Publicado: (2018)

The Mini-Craniotomy for cSDH Revisited: New Perspectives
por: Chen, Jefferson W., et al.
Publicado: (2021)

Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)
por: Heinrich, Michael C., et al.
Publicado: (2019)

Synchronous double gastric tumors: GIST or not GIST
por: Sayida, Sa’d, et al.
Publicado: (2020)

Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3
por: Cimini, Donatella, et al.
Publicado: (2009)

Use of SDHB immunohistochemistry to identify germline mutations of SDH genes
por: Gill, AJ
Publicado: (2012)

M5 segment aneurysm presenting as “pure acute SDH”
por: Singla, Navneet, et al.
Publicado: (2014)

Pneumocephalus is not a serious outcome after surgery for chronic SDH
por: Chaudhuri, Pratyush
Publicado: (2017)

Gene Expression Landscape of SDH-Deficient Gastrointestinal Stromal Tumors
por: Indio, Valentina, et al.
Publicado: (2021)

Rapid Detection of SdhB(P225F) and SdhB(H272R) Mutations in Boscalid Resistant Botrytis cinerea Strains by ARMS-PCR
por: Liu, Xin, et al.
Publicado: (2019)

Perforated small bowel GIST in an immunocompromised male
por: Dey, Courtney B., et al.
Publicado: (2019)

GIST and Ghrelin: To Be or Not to Be?
por: Spiridon, Irene Alexandra, et al.
Publicado: (2021)

An SDH-based optical transmission-system for applications in the high-energy physics
por: Reinecke, M, et al.
Publicado: (1996)

SDH/SONET Explained in Functional Models: Modeling the Optical Transport Network
por: Van Helvoort, Huub
Publicado: (2005)

Connection-oriented Networks: SONET/SDH, ATM, MPLS and Optical Networks
por: Perros, Harry G
Publicado: (2005)

Network recovery: protection and restoration of optical, SONET-SDH, IP, and MPLS
por: Vasseur, Jean-Philippe, et al.
Publicado: (2004)

The Social Determinants of Health (SDH) in Iran: A Systematic Review Article
por: BAHADORI, Mohammadkarim, et al.
Publicado: (2015)

A suppressor of dioxygenase inhibition in a yeast model of SDH deficiency
por: Beimers, William, et al.
Publicado: (2022)

Genomic and Metabolic Hallmarks of SDH- and FH-deficient Renal Cell Carcinomas
por: Yoo, Angela, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ek99bc76r1kpk9dt69sskbvhac