Cargando…

A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations?

Objective Target biopsy (TB) was defined to detect a higher rate of cancer with fewer cores. Today, however, the combined biopsy (CB; TB + standard prostate biopsy (SPB)) with even more cores has become more popular. We aimed to compare CB results with those of TB and SPB in patients in the gray zon...

Descripción completa

Detalles Bibliográficos
Autores principales: Demirtaş, Türev, Sönmez, Gökhan, Tombul, Şevket T, Demirtaş, Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913945/
https://www.ncbi.nlm.nih.gov/pubmed/31890368
http://dx.doi.org/10.7759/cureus.6160
_version_ 1783479719315898368
author Demirtaş, Türev
Sönmez, Gökhan
Tombul, Şevket T
Demirtaş, Abdullah
author_facet Demirtaş, Türev
Sönmez, Gökhan
Tombul, Şevket T
Demirtaş, Abdullah
author_sort Demirtaş, Türev
collection PubMed
description Objective Target biopsy (TB) was defined to detect a higher rate of cancer with fewer cores. Today, however, the combined biopsy (CB; TB + standard prostate biopsy (SPB)) with even more cores has become more popular. We aimed to compare CB results with those of TB and SPB in patients in the gray zone and, based on the outcomes, to determine whether TB has achieved its goal based on the expectation that higher cancer detection rates can be attained with fewer cores. Materials and methods This prospective study included patients with a prostate imaging reporting and data system (PI-RADS) ≥3 lesion and serum prostate-specific antigen (PSA) <10 ng/ml who underwent CB. All patients underwent two to five core biopsies per suspicious lesion (TB). Then, an SPB was administered to the same patients and in the same sessions. For fusion biopsy procedures, a fusion ultrasonography device with rigid software was used. Results A total of 404 patients were included in the study. The rate of clinically significant prostate cancer (sPCa) detection in TB, SPB, and CB was 30.2%, 25.5%, and 38.4%, respectively (p<0.05). The highest sPCa detection rate per core was detected in TB. For these patients, the CB results were accepted as the reference standard and then the histopathological upgrading of the lesions detected by SPB and TB was determined. Accordingly, higher histopathological upgrade rates were detected in SPB (10% and 25.7%). Conclusion We can say that the philosophy of detecting more cancers with a low number of cores, which was created when defining TB, was partially unsuccessful.
format Online
Article
Text
id pubmed-6913945
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-69139452019-12-30 A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations? Demirtaş, Türev Sönmez, Gökhan Tombul, Şevket T Demirtaş, Abdullah Cureus Urology Objective Target biopsy (TB) was defined to detect a higher rate of cancer with fewer cores. Today, however, the combined biopsy (CB; TB + standard prostate biopsy (SPB)) with even more cores has become more popular. We aimed to compare CB results with those of TB and SPB in patients in the gray zone and, based on the outcomes, to determine whether TB has achieved its goal based on the expectation that higher cancer detection rates can be attained with fewer cores. Materials and methods This prospective study included patients with a prostate imaging reporting and data system (PI-RADS) ≥3 lesion and serum prostate-specific antigen (PSA) <10 ng/ml who underwent CB. All patients underwent two to five core biopsies per suspicious lesion (TB). Then, an SPB was administered to the same patients and in the same sessions. For fusion biopsy procedures, a fusion ultrasonography device with rigid software was used. Results A total of 404 patients were included in the study. The rate of clinically significant prostate cancer (sPCa) detection in TB, SPB, and CB was 30.2%, 25.5%, and 38.4%, respectively (p<0.05). The highest sPCa detection rate per core was detected in TB. For these patients, the CB results were accepted as the reference standard and then the histopathological upgrading of the lesions detected by SPB and TB was determined. Accordingly, higher histopathological upgrade rates were detected in SPB (10% and 25.7%). Conclusion We can say that the philosophy of detecting more cancers with a low number of cores, which was created when defining TB, was partially unsuccessful. Cureus 2019-11-14 /pmc/articles/PMC6913945/ /pubmed/31890368 http://dx.doi.org/10.7759/cureus.6160 Text en Copyright © 2019, Demirtaş et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Urology
Demirtaş, Türev
Sönmez, Gökhan
Tombul, Şevket T
Demirtaş, Abdullah
A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations?
title A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations?
title_full A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations?
title_fullStr A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations?
title_full_unstemmed A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations?
title_short A Single-center Experience: Does MRI-guided Target Prostate Biopsy Meet Expectations?
title_sort single-center experience: does mri-guided target prostate biopsy meet expectations?
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913945/
https://www.ncbi.nlm.nih.gov/pubmed/31890368
http://dx.doi.org/10.7759/cureus.6160
work_keys_str_mv AT demirtasturev asinglecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations
AT sonmezgokhan asinglecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations
AT tombulsevkett asinglecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations
AT demirtasabdullah asinglecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations
AT demirtasturev singlecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations
AT sonmezgokhan singlecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations
AT tombulsevkett singlecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations
AT demirtasabdullah singlecenterexperiencedoesmriguidedtargetprostatebiopsymeetexpectations