Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation

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Human genetic studies implicate interleukin-27 (IL-27) in the pathogenesis of type 1 diabetes (T1D), but the underlying mechanisms remain largely unexplored. To further define the role of IL-27 in T1D, we generated non-obese diabetic (NOD) mice deficient in IL-27 or IL-27Rα. In contrast to wild-type...

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Detalles Bibliográficos
Autores principales: Ciecko, Ashley E., Foda, Bardees, Barr, Jennifer Y., Ramanathan, Sheela, Atkinson, Mark A., Serreze, David V., Geurts, Aron M., Lieberman, Scott M., Chen, Yi-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914223/
https://www.ncbi.nlm.nih.gov/pubmed/31801074
http://dx.doi.org/10.1016/j.celrep.2019.11.010
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