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Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

Misfolded proteins in the lumen of the endoplasmic reticulum (ER) are retrotranslocated into the cytosol and polyubiquitinated before being degraded by the proteasome. The multi-spanning ubiquitin ligase Hrd1 forms the retrotranslocation channel and associates with three other membrane proteins (Hrd...

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Detalles Bibliográficos
Autores principales:	Peterson, Brian G, Glaser, Morgan L, Rapoport, Tom A, Baldridge, Ryan D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914336/ https://www.ncbi.nlm.nih.gov/pubmed/31713515 http://dx.doi.org/10.7554/eLife.50903

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