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Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes. We have engineered IL-6 variants with different affinities to gp130 to investigate how cytokine receptor binding dwell-tim...

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Detalles Bibliográficos
Autores principales:	Martinez-Fabregas, Jonathan, Wilmes, Stephan, Wang, Luopin, Hafer, Maximillian, Pohler, Elizabeth, Lokau, Juliane, Garbers, Christoph, Cozzani, Adeline, Fyfe, Paul K, Piehler, Jacob, Kazemian, Majid, Mitra, Suman, Moraga, Ignacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914340/ https://www.ncbi.nlm.nih.gov/pubmed/31774398 http://dx.doi.org/10.7554/eLife.49314

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