Principles and applications of optogenetics in developmental biology

The development of multicellular organisms is controlled by highly dynamic molecular and cellular processes organized in spatially restricted patterns. Recent advances in optogenetics are allowing protein function to be controlled with the precision of a pulse of laser light in vivo, providing a pow...

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Autores principales: Krueger, Daniel, Izquierdo, Emiliano, Viswanathan, Ranjith, Hartmann, Jonas, Pallares Cartes, Cristina, De Renzis, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914371/
https://www.ncbi.nlm.nih.gov/pubmed/31641044
http://dx.doi.org/10.1242/dev.175067
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author Krueger, Daniel
Izquierdo, Emiliano
Viswanathan, Ranjith
Hartmann, Jonas
Pallares Cartes, Cristina
De Renzis, Stefano
author_facet Krueger, Daniel
Izquierdo, Emiliano
Viswanathan, Ranjith
Hartmann, Jonas
Pallares Cartes, Cristina
De Renzis, Stefano
author_sort Krueger, Daniel
collection PubMed
description The development of multicellular organisms is controlled by highly dynamic molecular and cellular processes organized in spatially restricted patterns. Recent advances in optogenetics are allowing protein function to be controlled with the precision of a pulse of laser light in vivo, providing a powerful new tool to perturb developmental processes at a wide range of spatiotemporal scales. In this Primer, we describe the most commonly used optogenetic tools, their application in developmental biology and in the nascent field of synthetic morphogenesis.
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spelling pubmed-69143712019-12-16 Principles and applications of optogenetics in developmental biology Krueger, Daniel Izquierdo, Emiliano Viswanathan, Ranjith Hartmann, Jonas Pallares Cartes, Cristina De Renzis, Stefano Development Article The development of multicellular organisms is controlled by highly dynamic molecular and cellular processes organized in spatially restricted patterns. Recent advances in optogenetics are allowing protein function to be controlled with the precision of a pulse of laser light in vivo, providing a powerful new tool to perturb developmental processes at a wide range of spatiotemporal scales. In this Primer, we describe the most commonly used optogenetic tools, their application in developmental biology and in the nascent field of synthetic morphogenesis. 2019-10-22 2019-10-22 /pmc/articles/PMC6914371/ /pubmed/31641044 http://dx.doi.org/10.1242/dev.175067 Text en https://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Article
Krueger, Daniel
Izquierdo, Emiliano
Viswanathan, Ranjith
Hartmann, Jonas
Pallares Cartes, Cristina
De Renzis, Stefano
Principles and applications of optogenetics in developmental biology
title Principles and applications of optogenetics in developmental biology
title_full Principles and applications of optogenetics in developmental biology
title_fullStr Principles and applications of optogenetics in developmental biology
title_full_unstemmed Principles and applications of optogenetics in developmental biology
title_short Principles and applications of optogenetics in developmental biology
title_sort principles and applications of optogenetics in developmental biology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914371/
https://www.ncbi.nlm.nih.gov/pubmed/31641044
http://dx.doi.org/10.1242/dev.175067
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