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Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release

The present study aimed to investigate the mechanism of intervertebral disc degeneration (IVDD) and identify an efficient treatment for low back pain. Rabbit annulus fibrosus stem cells (AFSCs) were treated with metformin and lipopolysaccharide (LPS). The results indicated that LPS induced HMGB1 rel...

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Detalles Bibliográficos
Autores principales:	Han, Yingchao, Yuan, Feng, Deng, Chao, He, Fan, Zhang, Yan, Shen, Hongxing, Chen, Zhi, Qian, Lie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914423/ https://www.ncbi.nlm.nih.gov/pubmed/31772144 http://dx.doi.org/10.18632/aging.102453

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