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Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

The inflammatory-associated factors interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are widely reported to be associated with intervertebral disc (IVD) degeneration (IVDD). N-acetyl-5-methoxytryptamine (melatonin) is a natural hormone secreted by the pineal gland whi...

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Detalles Bibliográficos
Autores principales:	Zhang, Yan, He, Fan, Chen, Zhi, Su, Qihang, Yan, Meijun, Zhang, Qiang, Tan, Jun, Qian, Lie, Han, Yingchao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914432/ https://www.ncbi.nlm.nih.gov/pubmed/31772145 http://dx.doi.org/10.18632/aging.102472

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