Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer

Breast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and i...

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Autores principales: Moliere, Sebastien, Oddou, Isabelle, Noblet, Vincent, Veillon, Francis, Mathelin, Carole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914793/
https://www.ncbi.nlm.nih.gov/pubmed/31844135
http://dx.doi.org/10.1038/s41598-019-55820-5
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author Moliere, Sebastien
Oddou, Isabelle
Noblet, Vincent
Veillon, Francis
Mathelin, Carole
author_facet Moliere, Sebastien
Oddou, Isabelle
Noblet, Vincent
Veillon, Francis
Mathelin, Carole
author_sort Moliere, Sebastien
collection PubMed
description Breast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and its prognostic value to predict recurrence. MRI BPE was visually and quantitatively evaluated before and after NAC in a retrospective cohort of 102 women with unilateral biopsy-proven invasive breast cancer. Pre-therapeutic BPE was not predictive of pathological response or recurrence. Quantitative post-therapeutic BPE was significantly decreased compared to pre-therapeutic value. Post-therapeutic quantitative BPE significantly predicted recurrence (HR = 6.38 (0.71, 12.06), p < 0.05).
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spelling pubmed-69147932019-12-18 Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer Moliere, Sebastien Oddou, Isabelle Noblet, Vincent Veillon, Francis Mathelin, Carole Sci Rep Article Breast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and its prognostic value to predict recurrence. MRI BPE was visually and quantitatively evaluated before and after NAC in a retrospective cohort of 102 women with unilateral biopsy-proven invasive breast cancer. Pre-therapeutic BPE was not predictive of pathological response or recurrence. Quantitative post-therapeutic BPE was significantly decreased compared to pre-therapeutic value. Post-therapeutic quantitative BPE significantly predicted recurrence (HR = 6.38 (0.71, 12.06), p < 0.05). Nature Publishing Group UK 2019-12-16 /pmc/articles/PMC6914793/ /pubmed/31844135 http://dx.doi.org/10.1038/s41598-019-55820-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Moliere, Sebastien
Oddou, Isabelle
Noblet, Vincent
Veillon, Francis
Mathelin, Carole
Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
title Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
title_full Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
title_fullStr Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
title_full_unstemmed Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
title_short Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
title_sort quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914793/
https://www.ncbi.nlm.nih.gov/pubmed/31844135
http://dx.doi.org/10.1038/s41598-019-55820-5
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