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Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China

This study aimed at estimating the effects of epidemiological risk factors for lung cancer in never-smokers. A multicenter and matched case-control study was conducted in the cities of Shijiazhuang, Xingtai, Qinhuangdao, Baoding, and Chengde in North China. It comprised 1,086 cases and 2,172 healthy...

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Autores principales: Liang, Di, Wang, Jingxi, Li, Daojuan, Shi, Jin, Jing, Jin, Shan, Baoen, He, Yutong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914814/
https://www.ncbi.nlm.nih.gov/pubmed/31921627
http://dx.doi.org/10.3389/fonc.2019.01354
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author Liang, Di
Wang, Jingxi
Li, Daojuan
Shi, Jin
Jing, Jin
Shan, Baoen
He, Yutong
author_facet Liang, Di
Wang, Jingxi
Li, Daojuan
Shi, Jin
Jing, Jin
Shan, Baoen
He, Yutong
author_sort Liang, Di
collection PubMed
description This study aimed at estimating the effects of epidemiological risk factors for lung cancer in never-smokers. A multicenter and matched case-control study was conducted in the cities of Shijiazhuang, Xingtai, Qinhuangdao, Baoding, and Chengde in North China. It comprised 1,086 cases and 2,172 healthy subjects as controls, all of whom had smoked fewer than 100 cigarettes in their lifetimes. Patients were newly diagnosed with lung cancer between January 2015 and December 2017. Each patient was matched to two control participants for sex and age (±5 years). Both univariate analysis and multivariate conditional logistic regression models were used to estimate the odds ratio (OR) and 95% confidence interval (95% CI). Subsequently, data were stratified by participant sex and different air quality conditions for analysis. Type of job, exposure to environmental tobacco smoke in the workplace or at home, above-average exposure to cooking oil fumes, depression, poor sleep quality, occupational exposure, cardiovascular diseases, and family history of cancer were revealed as significant risk factors for lung cancer in never-smokers. However, higher educational level, frequent use of a PM(2.5) mask, cooking using clean fuels, and consumption of dietary supplements and tea reduced the risk of lung cancer. Risk factors varied between males and females. In areas with air pollution, the number of risk factors was greater than elsewhere, and the magnitudes of their effects were different. Hence, focusing on these risk factors is important for the prevention and control of lung cancer in never-smokers.
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spelling pubmed-69148142020-01-09 Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China Liang, Di Wang, Jingxi Li, Daojuan Shi, Jin Jing, Jin Shan, Baoen He, Yutong Front Oncol Oncology This study aimed at estimating the effects of epidemiological risk factors for lung cancer in never-smokers. A multicenter and matched case-control study was conducted in the cities of Shijiazhuang, Xingtai, Qinhuangdao, Baoding, and Chengde in North China. It comprised 1,086 cases and 2,172 healthy subjects as controls, all of whom had smoked fewer than 100 cigarettes in their lifetimes. Patients were newly diagnosed with lung cancer between January 2015 and December 2017. Each patient was matched to two control participants for sex and age (±5 years). Both univariate analysis and multivariate conditional logistic regression models were used to estimate the odds ratio (OR) and 95% confidence interval (95% CI). Subsequently, data were stratified by participant sex and different air quality conditions for analysis. Type of job, exposure to environmental tobacco smoke in the workplace or at home, above-average exposure to cooking oil fumes, depression, poor sleep quality, occupational exposure, cardiovascular diseases, and family history of cancer were revealed as significant risk factors for lung cancer in never-smokers. However, higher educational level, frequent use of a PM(2.5) mask, cooking using clean fuels, and consumption of dietary supplements and tea reduced the risk of lung cancer. Risk factors varied between males and females. In areas with air pollution, the number of risk factors was greater than elsewhere, and the magnitudes of their effects were different. Hence, focusing on these risk factors is important for the prevention and control of lung cancer in never-smokers. Frontiers Media S.A. 2019-12-10 /pmc/articles/PMC6914814/ /pubmed/31921627 http://dx.doi.org/10.3389/fonc.2019.01354 Text en Copyright © 2019 Liang, Wang, Li, Shi, Jing, Shan and He. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liang, Di
Wang, Jingxi
Li, Daojuan
Shi, Jin
Jing, Jin
Shan, Baoen
He, Yutong
Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China
title Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China
title_full Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China
title_fullStr Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China
title_full_unstemmed Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China
title_short Lung Cancer in Never-Smokers: A Multicenter Case-Control Study in North China
title_sort lung cancer in never-smokers: a multicenter case-control study in north china
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914814/
https://www.ncbi.nlm.nih.gov/pubmed/31921627
http://dx.doi.org/10.3389/fonc.2019.01354
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