Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs

Technologies that induce targeted protein degradation by small molecules have been developed recently. Chimeric small molecules such as Proteolysis Targeting Chimeras (PROTACs) and Specific and Non-genetic IAP-dependent Protein Erasers (SNIPERs), and E3 modulators such as thalidomides, hijack the ce...

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Detalles Bibliográficos
Autores principales: Naito, Mikihiko, Ohoka, Nobumichi, Shibata, Norihito, Tsukumo, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914816/
https://www.ncbi.nlm.nih.gov/pubmed/31921772
http://dx.doi.org/10.3389/fchem.2019.00849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914816/
https://www.ncbi.nlm.nih.gov/pubmed/31921772
http://dx.doi.org/10.3389/fchem.2019.00849

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