Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line

Transcription factors OCT4, SOX2, KLF4, C-MYC, and NANOG (OSKM-N) regulate pluripotency and stemness, and their ectopic expression reprograms human and murine fibroblasts that constitute the key of regenerative medicine. To determine their contribution to cell transformation, we analyzed the gene ex...

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Detalles Bibliográficos
Autores principales: Ruiz, Graciela, Valencia-González, Heriberto A., Pérez-Montiel, Delia, Muñoz, Felipe, Ocadiz-Delgado, Rodolfo, Fernández-Retana, Jorge, Pérez-Plasencia, Carlos, Reséndis-Antonio, Osbaldo, Gariglio, Patricio, García-Carrancá, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914900/
https://www.ncbi.nlm.nih.gov/pubmed/31885625
http://dx.doi.org/10.1155/2019/7683817

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