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Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review
BACKGROUND: Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout. METHODS: We searched for relevant studies on PubMed, Embase, and the Cochrane...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914931/ https://www.ncbi.nlm.nih.gov/pubmed/31885677 http://dx.doi.org/10.1155/2019/9896757 |
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author | Chen, Pei-En Liu, Chia-Yu Chien, Wu-Hsiung Chien, Ching-Wen Tung, Tao-Hsin |
author_facet | Chen, Pei-En Liu, Chia-Yu Chien, Wu-Hsiung Chien, Ching-Wen Tung, Tao-Hsin |
author_sort | Chen, Pei-En |
collection | PubMed |
description | BACKGROUND: Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout. METHODS: We searched for relevant studies on PubMed, Embase, and the Cochrane Library without restrictions on language from inception until August 15, 2019. The risk of bias was evaluated using the PRISMA statement and checklist, and the methodological quality was assessed using the Cochrane Collaboration tool. RESULTS: The six studies included in this systematic review reported decreases in the incidence and severity of gout following the ingestion of cherries. Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. Overall, we observed a positive correlation between the consumption of tart cherry juice and a decrease in serum uric acid concentration. CONCLUSIONS: Current evidence supports an association between cherry intake and a reduced risk of gout attacks. Note however that we were unable to conduct effective meta-analysis due to a lack of relevant studies and a high degree of variation in the methodologies and metrics used in previous studies. Further comprehensive trials or long-term follow-up studies will be required to evaluate the efficacy of cherry intake in treating patients with gout or hyperuricemia. |
format | Online Article Text |
id | pubmed-6914931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-69149312019-12-29 Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review Chen, Pei-En Liu, Chia-Yu Chien, Wu-Hsiung Chien, Ching-Wen Tung, Tao-Hsin Evid Based Complement Alternat Med Review Article BACKGROUND: Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout. METHODS: We searched for relevant studies on PubMed, Embase, and the Cochrane Library without restrictions on language from inception until August 15, 2019. The risk of bias was evaluated using the PRISMA statement and checklist, and the methodological quality was assessed using the Cochrane Collaboration tool. RESULTS: The six studies included in this systematic review reported decreases in the incidence and severity of gout following the ingestion of cherries. Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. Overall, we observed a positive correlation between the consumption of tart cherry juice and a decrease in serum uric acid concentration. CONCLUSIONS: Current evidence supports an association between cherry intake and a reduced risk of gout attacks. Note however that we were unable to conduct effective meta-analysis due to a lack of relevant studies and a high degree of variation in the methodologies and metrics used in previous studies. Further comprehensive trials or long-term follow-up studies will be required to evaluate the efficacy of cherry intake in treating patients with gout or hyperuricemia. Hindawi 2019-12-04 /pmc/articles/PMC6914931/ /pubmed/31885677 http://dx.doi.org/10.1155/2019/9896757 Text en Copyright © 2019 Pei-En Chen et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Pei-En Liu, Chia-Yu Chien, Wu-Hsiung Chien, Ching-Wen Tung, Tao-Hsin Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title | Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_full | Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_fullStr | Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_full_unstemmed | Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_short | Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_sort | effectiveness of cherries in reducing uric acid and gout: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914931/ https://www.ncbi.nlm.nih.gov/pubmed/31885677 http://dx.doi.org/10.1155/2019/9896757 |
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