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Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone

BACKGROUND: Single-tablet antiretroviral therapy is currently the first-line choice for the treatment of HIV infection. Some therapeutic regimens contain the CYP3A4 inhibitor cobicistat, which can interact with drugs undergoing hepatic first-pass metabolism, leading to unintended adverse effects. CA...

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Autores principales: Pineda-Reyes, Roberto, Klochko, Alena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914985/
https://www.ncbi.nlm.nih.gov/pubmed/31885960
http://dx.doi.org/10.1155/2019/8243868
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author Pineda-Reyes, Roberto
Klochko, Alena
author_facet Pineda-Reyes, Roberto
Klochko, Alena
author_sort Pineda-Reyes, Roberto
collection PubMed
description BACKGROUND: Single-tablet antiretroviral therapy is currently the first-line choice for the treatment of HIV infection. Some therapeutic regimens contain the CYP3A4 inhibitor cobicistat, which can interact with drugs undergoing hepatic first-pass metabolism, leading to unintended adverse effects. CASE PRESENTATION: A 41-year-old man presented to the HIV clinic following a visit to the Emergency Department. His CD4(+) count was 1,271 cells/μL, and viral load was undetectable in the previous month. The patient was on an antiretroviral therapy regimen containing cobicistat. He reported using a self-initiated over-the-counter fluticasone nasal spray for at least 2 weeks prior. He had a history of positive tuberculin skin test and a negative chest X-ray within the past year. He denied cough and was in no respiratory distress. A chest CT scan revealed a new thick-walled cavitary nodule in the right upper lobe. A CT-guided biopsy of the lesion yielded Mycobacterium tuberculosis. CONCLUSIONS: HIV-infected individuals have higher risk for tuberculosis reactivation regardless of their CD4(+) count. Fluticasone's hepatic metabolism is bypassed in the presence of CYP3A4 inhibitors, which increases its systemic bioavailability and the risk for impaired immunity. The goal of this report is to increase awareness among physicians about the potential adverse outcomes from the interaction of these drugs.
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spelling pubmed-69149852019-12-29 Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone Pineda-Reyes, Roberto Klochko, Alena Case Rep Infect Dis Case Report BACKGROUND: Single-tablet antiretroviral therapy is currently the first-line choice for the treatment of HIV infection. Some therapeutic regimens contain the CYP3A4 inhibitor cobicistat, which can interact with drugs undergoing hepatic first-pass metabolism, leading to unintended adverse effects. CASE PRESENTATION: A 41-year-old man presented to the HIV clinic following a visit to the Emergency Department. His CD4(+) count was 1,271 cells/μL, and viral load was undetectable in the previous month. The patient was on an antiretroviral therapy regimen containing cobicistat. He reported using a self-initiated over-the-counter fluticasone nasal spray for at least 2 weeks prior. He had a history of positive tuberculin skin test and a negative chest X-ray within the past year. He denied cough and was in no respiratory distress. A chest CT scan revealed a new thick-walled cavitary nodule in the right upper lobe. A CT-guided biopsy of the lesion yielded Mycobacterium tuberculosis. CONCLUSIONS: HIV-infected individuals have higher risk for tuberculosis reactivation regardless of their CD4(+) count. Fluticasone's hepatic metabolism is bypassed in the presence of CYP3A4 inhibitors, which increases its systemic bioavailability and the risk for impaired immunity. The goal of this report is to increase awareness among physicians about the potential adverse outcomes from the interaction of these drugs. Hindawi 2019-12-03 /pmc/articles/PMC6914985/ /pubmed/31885960 http://dx.doi.org/10.1155/2019/8243868 Text en Copyright © 2019 Roberto Pineda-Reyes and Alena Klochko. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Pineda-Reyes, Roberto
Klochko, Alena
Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone
title Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone
title_full Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone
title_fullStr Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone
title_full_unstemmed Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone
title_short Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone
title_sort early diagnosis of latent tuberculosis reactivation due to drug interaction between cobicistat and intranasal fluticasone
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914985/
https://www.ncbi.nlm.nih.gov/pubmed/31885960
http://dx.doi.org/10.1155/2019/8243868
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